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Figure 3 | Parasites & Vectors

Figure 3

From: An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3

Figure 3

Multiple sequence alignment of GSK-3 and CRK3 from three related Leishmania species. The multiple sequence alignment depicts the high homology between GSK-3 and CRK3 of three Leishmania species, namely L. donovani, L. infantum and L. major (Uniprot codes: A6N857, A4HXQ3, Q4QE15 for GSK-3 and Q4K8Z1, A4ICT0, Q96526 for CRK3, respectively). The gatekeeper positions as well as the three non-conserved residues of the ribose sub-site are highlighted by green stars and the glycine-rich loop is marked by a green bracket. Alignment was performed using ClustalW with default settings and the depiction was prepared using ESPript software (http://espript.ibcp.fr) [37, 38].

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