Skip to main content

Table 3 Definitions and values of the parameters explored in the sensitivity analysis

From: Modelling the impact of ivermectin on River Blindness and its burden of morbidity and mortality in African Savannah: EpiOncho projections

Parameters Values
Initial endemicity: pre-control (baseline) microfilarial prevalence in the overall population (all ages), as percentage 40% (mesoendemic), 60% (hyperendemic), 80% (highly hyperendemic)
Therapeutic coverage: overall proportion of the total population receiving ivermectin at each round, as percentage 60% (moderate) and 80% (high)
Proportion of systematic non-compliers: fraction of the eligible population who never take treatment, as percentage 0.1% (lower) and 5% (higher) treatment adherence
Anti-macrofilarial action of ivermectin: per dose, cumulative reduction in microfilarial production by ivermectin-exposed female adult worms[23, 29], as percentage 7% (small) and 30% (large) anti-macrofilarial effect
Relationship between infection and troublesome itch: nonlinear regression coefficient of the association between prevalence of adult female worms and that of troublesome itch[26] (see also eqn. S.16 of Additional file1) α2 ± 25% (stronger or weaker association between prevalence of female worms and prevalence of troublesome itch