Parameters | Values |
---|---|
Initial endemicity: pre-control (baseline) microfilarial prevalence in the overall population (all ages), as percentage | 40% (mesoendemic), 60% (hyperendemic), 80% (highly hyperendemic) |
Therapeutic coverage: overall proportion of the total population receiving ivermectin at each round, as percentage | 60% (moderate) and 80% (high) |
Proportion of systematic non-compliers: fraction of the eligible population who never take treatment, as percentage | 0.1% (lower) and 5% (higher) treatment adherence |
Anti-macrofilarial action of ivermectin: per dose, cumulative reduction in microfilarial production by ivermectin-exposed female adult worms[23, 29], as percentage | 7% (small) and 30% (large) anti-macrofilarial effect |
Relationship between infection and troublesome itch: nonlinear regression coefficient of the association between prevalence of adult female worms and that of troublesome itch[26] (see also eqn. S.16 of Additional file1) | α2 ± 25% (stronger or weaker association between prevalence of female worms and prevalence of troublesome itch |