Figure 1

Summary of results for the identification and classification of GPCRs in Schistosoma haematobium and S. mansoni. Top to bottom: First, from the inferred proteomes [47, 49], the numbers of sequences with transmembrane (TM) domains, the numbers of GPCRs of each class predicted by Hidden Markov Models (HMMs) and the numbers of significant matches to known* GPCRs (from databases such as SwissProt, TrEMBL and KEGG) are presented. Second, the preliminary sets of GPCRs categorised to the class level are shown, after filtering sequences that did not contain 5–8 transmembrane domains. Third, orthologs not detected in published gene sets were identified in the phylogenetic trees generated (paired one-to-one orthologs were expected for the two closely related schistosome species). Fourth, the final sets of GPCRs for each class, including the numbers of sequences found by homology but not predicted by HMMs, are shown. Finally, the numbers following sub-classification by SVM1 (class A subclass) and SVM2 (class A amine sub-classification – ligand affinity) are given.