Voltage gated sodium channel and the 1016 and 1534 alleles found in Brazilian Aedes aegypti populations. The NaV is represented with its four domains (I-IV), each with the six transmembrane segments (S1-S6). The voltage sensitive S4 and the pore forming S6 segments are colored in blue and green, respectively (scheme adapted from ). The 1016 and 1534 kdr sites in Aedes aegypti are indicated. Mutant amino acids are underlined.