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Table 1 The efficacy of papaya CPs and albendazole against low and high intensity T. suis infections

From: Cysteine proteinases from papaya (Carica papaya) in the treatment of experimental Trichuris suis infection in pigs: two randomized controlled trials

  n Mean FECs at D-1 (EPG) (95% CI) Mean FECs at D+6 (EPG) (96% CI) ERR (%) (95% CI) Mean WCs at D7 (95% CI) WRR (%) (95% CI)
Low infection intensity (inoculum = 300 eggs)
  CP450 6 8.3(0.0; 25.0) 8.3(0.0; 25.0) 98.3(92.7; 100) 1.3(0.2; 2.8) 99.0*(97.7; 99.9)
  ALB 6 8.3(0.0; 25.0) 175.0(16.7; 358.3) 64.4(-15.8; 96.3) 80.2(40.8; 122.0) 39.0*(2.4; 69.1)
  Control 6 16.7(0; 50.0) 491.7(183.3; 800.0) _ 131.5(107.2; 161.3) _
High infection intensity (inoculum = 3,000 eggs)
  CP450 5** 420.0(60.0; 780.0) 100.0(10.0; 230.0) 98.9*(95.5; 99.9) 29.2(3.2; 63.2) 97.4*(94.3; 99.7)
  ALB 6 483.3(116.7; 916.7) 3800.0(1908.3; 5666.7) 59.0*(-47.0; 83.4) 877.2(597.0; 1,094.3) 23.2*(-7.8; 49.7)
  Control 6 366.7(58.3; 800.0) 9266.7(2683.3; 17416.7) _ 1142.2(893.0; 1,419.0) _
  1. The fecal egg counts (FEC) at day (D) -1, mean worm counts (WC) at D+7 and the reduction in WC at D+7 compared to the control group (WCR).
  2. *pair-wise comparison between CP450 and ALB revealed a significant difference with p-value <0.01; **One animal which received 3,000 eggs of T. suis and which was assigned to the CP450 treatment died in the course of trial. Autopsy did not reveal any causal association between the treatment and death.