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Table 2 The efficacy of four doses of papaya CPs against high intensity T. suis infections

From: Cysteine proteinases from papaya (Carica papaya) in the treatment of experimental Trichuris suis infection in pigs: two randomized controlled trials

Treatment arm n Mean FEC at D-1 (EPG) (95% CI) Mean FEC at D+6(EPG) (95% CI) ERR (%) (95% CI) Mean WC at D+7 (95% CI) WRR (%) (95% CI)
CP45 6 500.0(41.7; 1,200) 5416.7(2200.0; 9233.3) 2.1*(-629.8; 68.9) 976.5(697.3; 1,256.1) -14.0*(-213.7; 36.1)
CP115 6 233.3(16.7; 558.3) 1425.0(183.3; 2908.3) 74.2(-98.1; 96.9) 278.5(64.7; 551.7) 67.5(-3.4; 93.9)
CP225 6 241.7(50.0; 533.5) 808.3(208.3; 1741.7) 85.4(-15.4; 97.1) 160.3(61.3; 265.8) 81.3(43.7; 93.9)
CP450 6 441.7(25.0; 1,150.0) 41.7(0.0; 108.3) 99.2*(93.6; 100) 8.5(2.7; 15.7) 99.0*(97.0; 99.7)
Control 6 308.3(33.3; 733.3) 5533.3(758.3; 11608.3) _ 856.3(328.7; 1,384.0) _
  1. The mean fecal egg counts (FEC) at day (D) -1, mean worm counts (WC) at D+7 and the reduction in WC at D+7 compared to the control group (WCR) for a single-oral dose of 45, 115, 225, and 450 μmol papaya CPs (P45, P115, P225 and P450).
  2. *pair-wise comparison between CP450 and CP45 revealed a significant difference with p-value <0.01.