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Table 4 Pupal development control from eggs of parent fleas fed on blood containing fluralaner at sub-insecticidal concentrations

From: Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment

Fluralaner (ng/mL) Pupal development control (%)
Exposure daya
  3 4 5 8 9 10 Meanb
50.0 NA NA NA NA NA NA NA
25.0 NA NA NA NA NA NA NA
12.5 100 NA NA 55.2 100 NA 85.1
6.25 90.2 92.4 87.3 86.4 89.9 86.0 88.7
3.13 66.3 68.9 61.7 70.3 62.1 57.4 64.5
1.56 35.3 36.3 34.6 35.5 41.6 27.2 35.1
0.78 7.5 11.4 16.7 10.8 11.9 14.5 12.1
0.39 9.8 0 1.5 3.3 6.3 0.8 3.6
0.19 8.8 0.2 6.8 0 2.7 0 3.1
0.09 9.1 4.5 1.4 0 5.9 2.9 4.0
  1. aNo pupal counts were performed on exposure days 6 and 7.
  2. bArithmetic mean.
  3. NA: not applicable because fleas were either killed or did not lay eggs (Table 1 and Table 2).