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Table 6 Flea-control efficacy on treated dogs (25 mg fluranaler/kg body weight) compared with untreated dogs in a simulated home environment

From: Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment

Day post treatment

Mean flea numbers (arithmetic/geometric)

Efficacya(%)

P-value

 

Control group

Treated group

  

-1

52.3/26.4

35.0/14.1

N/A

N/A

1

12.8/6.0

0/0

100/100

0.001

7

5.1/1.8

0/0

100/100

0.021

14

7.1/2.7

0/0

100/100

0.012

21

16.5/4.1

0/0

100/100

0.011

28

53.2/24.8

0/0

100/100

0.000

35

44.1/15.7

0/0

100/100

0.000

42

42.6/10.8

0/0

100/100

0.002

49

48.7/20.6

0.1/0.1

99.8/99.7

0.000

56

57.1/40.6

0.1/0.1

99.8/99.8

0.000

63

42.3/25.6

0/0

100/100

0.000

70

30.0/16.2

0.1/0.1

99.7/99.6

0.000

77

21.9/12.3

0/0

100/100

0.000

84

40.7/33.2

0/0

100/100

0.000

  1. aEfficacy calculated from arithmetic/geometric mean flea counts.
  2. NA: not applicable.