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Table 6 Flea-control efficacy on treated dogs (25 mg fluranaler/kg body weight) compared with untreated dogs in a simulated home environment

From: Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment

Day post treatment Mean flea numbers (arithmetic/geometric) Efficacya(%) P-value
  Control group Treated group   
-1 52.3/26.4 35.0/14.1 N/A N/A
1 12.8/6.0 0/0 100/100 0.001
7 5.1/1.8 0/0 100/100 0.021
14 7.1/2.7 0/0 100/100 0.012
21 16.5/4.1 0/0 100/100 0.011
28 53.2/24.8 0/0 100/100 0.000
35 44.1/15.7 0/0 100/100 0.000
42 42.6/10.8 0/0 100/100 0.002
49 48.7/20.6 0.1/0.1 99.8/99.7 0.000
56 57.1/40.6 0.1/0.1 99.8/99.8 0.000
63 42.3/25.6 0/0 100/100 0.000
70 30.0/16.2 0.1/0.1 99.7/99.6 0.000
77 21.9/12.3 0/0 100/100 0.000
84 40.7/33.2 0/0 100/100 0.000
  1. aEfficacy calculated from arithmetic/geometric mean flea counts.
  2. NA: not applicable.