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Figure 1 | Parasites & Vectors

Figure 1

From: Engineered single nucleotide polymorphisms in the mosquito MEK docking site alter Plasmodium berghei development in Anopheles gambiae

Figure 1

Amino acid alignment of human MEK1 and MEK2 with Anopheles gambiae MEK. Human (Hs) MEK1 and MEK2 and A. gambiae (Ag) MEK show significant overall conservation with high amino acid identity and similarity, including conservation in the docking site or D-site (blue box) and the catalytic domain (orange box). Lysine residues at positions 3 and 6 (yellow boxes) in the A. gambiae MEK allele were mutated to methionine (M). The key serine residues within the catalytic domain at positions 243 and 247 (red boxes) were mutated to aspartic acid (D) and glutamic acid (E), respectively. Human MEK1 [Genbank: NP_002746], human MEK2 [Genbank: NP_109587] and A. gambiae MEK1 [Genbank: XP_322064] protein sequences were aligned using the MUSCLE method with default settings in Geneious [26].

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