Identification of two novel HSP90 proteins in Babesia orientalis: molecular characterization, and computational analyses of their structure, function, antigenicity and inhibitor interaction

Table 2 Interaction of Babesia orientalis HSP90-A and B isoforms with inhibitors using docking analysis

Name	Protein showing interaction	Template ID	PDB code
Geldanamycin	BoHSP90-A, BoHSP90-B	Gmy1	2exl
Radamide	BoHSP90-A, BoHSP90-B	Rda1001	2gfd
Redicicol	BoHSP90-A, BoHSP90-B	Rdc301	1u0z
Dihydroxyphenylpyrazoles	BoHSP90-A, BoHSP90-B	4BC401	1yc1
PU8(8-(2-chloro-3,4,5-trimethoxy-benzyl)-2-fluoro-9-pent-4-ylnyl-9 h-purin-6-ylamine)	BoHSP90-B	PU11224	1uyf
PU11 (8-(2,5-dimethoxy-benzyl)-2-fluoro-9- pent-9 h-purin-6-ylamine)	BoHSP90-A	Puz1224	1uyi
1-(2-phenol)-2-naphthol	BoHSP90-A, BoHSP90-B	AB41226	2bz5
3,4-diaryl pyrazole resorcinol (CCT018159)	BoHSP90-A, BoHSP90-B	Ct51224	2bt0
4-amino derivative of 3,4-diaryl pyrazole (4-chloro-6-(4-piperazin-1-yl-1 h-pyrazol-3-yl)-benzene-1,2-diol)	BoHSP90-B	4BH1224	2ccs

The template IDs are the identification numbers of inhibitors in RCSB Protein Data Bank. The proteins complexed with the inhibitors are indicated by PBD codes.

ISSN: 1756-3305