Figure 4From: Cross-protective effect of a combined L5 plus L3 Leishmania major ribosomal protein based vaccine combined with a Th1 adjuvant in murine cutaneous and visceral leishmaniasisHumoral response against the recombinant antigens following infection with L. amazonensis (A) or L. chagasi (B). Nine weeks after parasite challenge vaccinated and control mice (n = 4 per group) were bled and sera were individually tested by ELISA for specific anti-LmL3 and anti-LmL5 antibody responses of both IgG1 and IgG2a isotype at 1/200 dilution. Each bar represents the mean + standard deviation (SD) of data from four individual mice. * P < 0.05 indicates significant increase in the optical density between LmL3 + LmL5 + CpG-ODN vaccinated mice and both control groups. Data shown are representative of two independent experiments with similar results.Back to article page