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Figure 1 | Parasites & Vectors

Figure 1

From: The pathogenesis of optic neuritis caused by Angiostrongylus cantonensis in BALB/c mice

Figure 1

Retinal histopathology caused by A. cantonensis . (A1-E1): Retinas from mice infected with A. cantonensis for 0 d, 7 d, 14 d, 21 d, and 28 d, respectively. The ganglion cell layer shows inflammatory cell infiltration (black arrow in D1) at day 21. The inflammation has decreased by day 28 (E1). Scale bar = 100 mm. (A2-E2): The ganglion cells of mice infected with A. cantonensis for 0 d, 7 d, 14 d, 21 d, and 28 d, respectively observed with a scanning electron microscope. On day 14, obvious swelling can be observed in the cytoplasm of ganglion cells (black arrow in C2) and becomes more pronounced on day 21 (black arrow in D2). By day 28 the swelling has decreased (black arrow in E2). Scale bar = 1 μm. (A3-E3): The inner nuclear layer of mice infected with A. cantonensis for 0 d, 7 d, 14 d, 21 d, and 28 d respectively. Inner nuclear layer swelling is apparent on day 14 (black arrow in C3) and was more serious on day 21 (black arrow in D3). Swelling had decreased by day 28 (black arrow in E3). Scale bar = 1 μm. (F): Retinal thickness, as seen under a light microscope, in control, 7 d, 14 d, 21 d, and 28 d respectively after infection with A. cantonensis. Data are mean ± SEM. *Statistically significant when compared with control (0 d infection) (P < 0.05); # Statistically significant when compared with infection for 14 d (P < 0.05); Statistically significant when compared with infection for 21 d; Statistically significant when compared with infection for 28 d. Scale bar = 0.5 μm.

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