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Table 3 Gene and genotype frequencies of seven sodium channel gene mutations calculated in six populations of Cx. p. quinquefasciatus

From: Sodium channel point mutations associated with pyrethroid resistance in Chinese strains of Culex pipiens quinquefasciatus (Diptera: Culicidae)

Mutation

Population

n

Genotype frequency and gene frequency (%)

SS1

RS2

RR3

R4

V250M

FH

49

61.2

34.7

4.10

21.4

 

PX

31

41.9

48.4

9.70

33.9

 

BA

29

55.2

37.9

6.90

25.9

 

ZJ

31

48.4

51.6

0.00

25.8

 

CL

32

65.6

34.4

0.00

17.2

 

LS

36

61.1

27.8

11.1

25.0

R436K

FH

27

7.40

92.6

0.00

46.3

 

PX

12

0.00

100

0.00

50.0

 

BA

10

0.00

100

0.00

50.0

 

ZJ

20

0.00

100

0.00

50.0

 

CL

13

0.00

100

0.00

50.0

 

LS

15

6.70

93.3

0.00

46.7

M943V

FH

32

34.4

65.6

0.00

32.8

 

PX

38

44.7

55.3

0.00

27.6

 

BA

31

32.3

67.7

0.00

33.9

 

ZJ

33

48.5

51.5

0.00

25.8

 

CL

32

28.1

71.9

0.00

35.9

 

LS

31

16.1

83.9

0.00

41.9

I973T

FH

32

46.9

53.1

0.00

26.7

 

PX

38

39.5

60.5

0.00

30.3

 

BA

31

29.0

71.0

0.00

35.5

 

ZJ

33

51.5

48.5

0.00

24.2

 

CL

32

37.5

62.5

0.00

31.3

 

LS

31

32.3

67.7

0.00

33.9

L1035F

FH

35

0.00

11.4

68.6

74.3

 

PX

38

5.26

18.4

44.7

54.0

 

BA

31

16.1

45.2

29.0

51.6

 

ZJ

33

9.09

45.5

6.06

28.8

 

CL

32

3.13

68.8

21.9

56.3

 

LS

31

0.00

12.9

58.1

64.5

L1035S

FH

35

0.00

20.0

0.00

10.0

 

PX

38

5.26

31.6

0.00

15.8

 

BA

31

16.1

9.68

0.00

4.84

 

ZJ

33

9.09

36.4

3.03

21.2

 

CL

32

3.13

6.25

0.00

3.13

 

LS

31

0.00

25.8

3.23

16.1

E1901D

FH

32

34.4

50.0

15.6

40.6

 

PX

31

38.7

58.1

3.22

32.3

 

BA

34

55.9

44.1

0.00

22.1

 

ZJ

30

83.3

16.7

0.00

8.33

 

CL

22

40.9

59.1

0.00

29.6

 

LS

38

34.2

41.1

23.7

44.7

  1. (“S” = the amino acid sequence of the sodium channel gene listed in GenBank (Accession No.: AB453977.1). “R” = mutant variants of “S”. “SS” = “S” homozygotes, “RS” = heterozygotes, and “RR” = “R” homozygotes).
  2. 1SS frequency = SS ÷ (SS + RS + RR) × 100%; 2RS frequency = RS ÷ (SS + RS + RR) × 100%.
  3. 3RR frequency = RR ÷ (SS + RS + RR) × 100%; 4R frequency = (RR + 1/2RS) ÷ (SS + RS + RR) × 100%.