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Table 3 Gene and genotype frequencies of seven sodium channel gene mutations calculated in six populations of Cx. p. quinquefasciatus

From: Sodium channel point mutations associated with pyrethroid resistance in Chinese strains of Culex pipiens quinquefasciatus (Diptera: Culicidae)

Mutation Population n Genotype frequency and gene frequency (%)
SS1 RS2 RR3 R4
V250M FH 49 61.2 34.7 4.10 21.4
  PX 31 41.9 48.4 9.70 33.9
  BA 29 55.2 37.9 6.90 25.9
  ZJ 31 48.4 51.6 0.00 25.8
  CL 32 65.6 34.4 0.00 17.2
  LS 36 61.1 27.8 11.1 25.0
R436K FH 27 7.40 92.6 0.00 46.3
  PX 12 0.00 100 0.00 50.0
  BA 10 0.00 100 0.00 50.0
  ZJ 20 0.00 100 0.00 50.0
  CL 13 0.00 100 0.00 50.0
  LS 15 6.70 93.3 0.00 46.7
M943V FH 32 34.4 65.6 0.00 32.8
  PX 38 44.7 55.3 0.00 27.6
  BA 31 32.3 67.7 0.00 33.9
  ZJ 33 48.5 51.5 0.00 25.8
  CL 32 28.1 71.9 0.00 35.9
  LS 31 16.1 83.9 0.00 41.9
I973T FH 32 46.9 53.1 0.00 26.7
  PX 38 39.5 60.5 0.00 30.3
  BA 31 29.0 71.0 0.00 35.5
  ZJ 33 51.5 48.5 0.00 24.2
  CL 32 37.5 62.5 0.00 31.3
  LS 31 32.3 67.7 0.00 33.9
L1035F FH 35 0.00 11.4 68.6 74.3
  PX 38 5.26 18.4 44.7 54.0
  BA 31 16.1 45.2 29.0 51.6
  ZJ 33 9.09 45.5 6.06 28.8
  CL 32 3.13 68.8 21.9 56.3
  LS 31 0.00 12.9 58.1 64.5
L1035S FH 35 0.00 20.0 0.00 10.0
  PX 38 5.26 31.6 0.00 15.8
  BA 31 16.1 9.68 0.00 4.84
  ZJ 33 9.09 36.4 3.03 21.2
  CL 32 3.13 6.25 0.00 3.13
  LS 31 0.00 25.8 3.23 16.1
E1901D FH 32 34.4 50.0 15.6 40.6
  PX 31 38.7 58.1 3.22 32.3
  BA 34 55.9 44.1 0.00 22.1
  ZJ 30 83.3 16.7 0.00 8.33
  CL 22 40.9 59.1 0.00 29.6
  LS 38 34.2 41.1 23.7 44.7
  1. (“S” = the amino acid sequence of the sodium channel gene listed in GenBank (Accession No.: AB453977.1). “R” = mutant variants of “S”. “SS” = “S” homozygotes, “RS” = heterozygotes, and “RR” = “R” homozygotes).
  2. 1SS frequency = SS ÷ (SS + RS + RR) × 100%; 2RS frequency = RS ÷ (SS + RS + RR) × 100%.
  3. 3RR frequency = RR ÷ (SS + RS + RR) × 100%; 4R frequency = (RR + 1/2RS) ÷ (SS + RS + RR) × 100%.