V1 | V2 | V3 | V4 | |
---|---|---|---|---|
(enrollment) | (Day 28) | (Day 56) | (Day 84) | |
Number of Primary Dogs | ||||
Fluralaner | 117 | 113 | 108 | 106 |
Spinosad + Amitraz | 39 | 38 | 34 | 32 |
Geometric mean flea count (95% CI) | ||||
Fluralaner | 32.2 (27.1 – 38.2) | 0.1 (0.0 – 0.2) | 0.1 (0.0 – 0.1) | 0.1 (0.0 – 0.1) |
Spinosad + Amitraz | 32.6 (23.6 – 44.9) | 1.3 (0.7 – 2.0) | 0.2 (0.0 – 0.4) | 0.1 (0.0 – 0.2) |
P-value for comparison* | 0.9469 | <0.0001 | 0.1766 | 0.2189 |
% effectiveness (reduction from baseline) | ||||
Fluralaner | NA | 99.7% | 99.8% | 99.8% |
Spinosad + Amitraz | NA | 96.1% | 99.5% | 99.6% |
% flea-free primary dogs | ||||
Fluralaner | NA | 91.1% | 95.4% | 95.3% |
Spinosad + Amitraz | NA | 44.7% | 88.2% | 84.4% |
P-value for comparison** | NA | <0.0001 | 0.1364 | 0.0370 |