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Table 2 Primary dog geometric mean flea counts, percentage reduction from baseline, and flea-free dogs for treated dogs at each visit

From: A randomized, blinded, controlled USA field study to assess the use of fluralaner tablets in controlling canine flea infestations

 

V1

V2

V3

V4

(enrollment)

(Day 28)

(Day 56)

(Day 84)

Number of Primary Dogs

 Fluralaner

117

113

108

106

 Spinosad + Amitraz

39

38

34

32

Geometric mean flea count (95% CI)

 Fluralaner

32.2 (27.1 – 38.2)

0.1 (0.0 – 0.2)

0.1 (0.0 – 0.1)

0.1 (0.0 – 0.1)

 Spinosad + Amitraz

32.6 (23.6 – 44.9)

1.3 (0.7 – 2.0)

0.2 (0.0 – 0.4)

0.1 (0.0 – 0.2)

 P-value for comparison*

0.9469

<0.0001

0.1766

0.2189

% effectiveness (reduction from baseline)

 Fluralaner

NA

99.7%

99.8%

99.8%

 Spinosad + Amitraz

NA

96.1%

99.5%

99.6%

% flea-free primary dogs

 Fluralaner

NA

91.1%

95.4%

95.3%

 Spinosad + Amitraz

NA

44.7%

88.2%

84.4%

 P-value for comparison**

NA

<0.0001

0.1364

0.0370

  1. “NA” indicates that the value or calculation is “not applicable”. No effectiveness comparison was performed at V1 and no primary dogs were flea-free at V1.
  2. *- P-value for comparison of model least squares means parameter estimates.
  3. **- P-value for comparison of percentages using non-parametric asymptotic approach.