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Table 2 Primary dog geometric mean flea counts, percentage reduction from baseline, and flea-free dogs for treated dogs at each visit

From: A randomized, blinded, controlled USA field study to assess the use of fluralaner tablets in controlling canine flea infestations

  V1 V2 V3 V4
(enrollment) (Day 28) (Day 56) (Day 84)
Number of Primary Dogs
 Fluralaner 117 113 108 106
 Spinosad + Amitraz 39 38 34 32
Geometric mean flea count (95% CI)
 Fluralaner 32.2 (27.1 – 38.2) 0.1 (0.0 – 0.2) 0.1 (0.0 – 0.1) 0.1 (0.0 – 0.1)
 Spinosad + Amitraz 32.6 (23.6 – 44.9) 1.3 (0.7 – 2.0) 0.2 (0.0 – 0.4) 0.1 (0.0 – 0.2)
 P-value for comparison* 0.9469 <0.0001 0.1766 0.2189
% effectiveness (reduction from baseline)
 Fluralaner NA 99.7% 99.8% 99.8%
 Spinosad + Amitraz NA 96.1% 99.5% 99.6%
% flea-free primary dogs
 Fluralaner NA 91.1% 95.4% 95.3%
 Spinosad + Amitraz NA 44.7% 88.2% 84.4%
 P-value for comparison** NA <0.0001 0.1364 0.0370
  1. “NA” indicates that the value or calculation is “not applicable”. No effectiveness comparison was performed at V1 and no primary dogs were flea-free at V1.
  2. *- P-value for comparison of model least squares means parameter estimates.
  3. **- P-value for comparison of percentages using non-parametric asymptotic approach.