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Table 1 Components of the insect Immune Deficiency (Imd) pathway and antimicrobial peptides (AMPs) identified in the C. sonorensis transcriptome

From: Gene discovery and differential expression analysis of humoral immune response elements in female Culicoides sonorensis (Diptera: Ceratopogonidae)

Description

Acc. No.

Seq. no.

Aedes Hit

Culex Hit

e-Value

Commentsa

Receptors

      

Peptidoglycan Recognition Protein (Long; PGRP-LC)

GAWM01004359

m.21976

AAEL013112

CPIJ006560

4.49e-23

Complete; cytoplasmic, TM and PGRP domain

PGRP-LC

GAWM01003592

m.19794

AAEL014640

CPIJ006561

1.90e-40

Complete; cytoplasmic, TM and PGRP domain

PGRP-LC

GAWM01011033

m.42666

AAEL014640

CPIJ006561

1.90e-40

Complete; cytoplasmic, TM and PGRP domain

PGRP-LC

GAWM01011035

m.42672

AAEL014640

CPIJ006561

1.90e-40

Complete; cytoplasmic, TM and PGRP domain

PGRP-LC

GAWM01011037

m.42675

AAEL014640

CPIJ006561

7.24e-43

Complete; cytoplasmic, TM and PGRP domain

PGRP-LC

GAWM01011039

m.42683

AAEL014640

CPIJ006561

1.90e-40

Complete; cytoplasmic, TM and PGRP domain

PGRP-LC

GAWM01000194

m.10444

AAEL014989

CPIJ008514

1.30e-22

Complete; cytoplasmic, TM and PGRP domain

Signaling

      

DREDD (Caspase-8)

GAWM01000519

m.11119

AAEL014148

CPIJ009056

4.93e-66

Complete; death related ced-3 nedd2-like; complete ICE domain

Inhibitor of apoptosis (IAP)

GAWM01008211

m.33483

AAEL006633

CPIJ019231

4.4e-146

Complete; 3 BIR and one ring domain

tak1-associated binding protein (TAB)

GAWM01006076

m.27286

n/a

CPIJ000820

5.27e-21

Confirmed; ubiquitin domain (CUE) present

tak1 (MAP3K)

GAWM01010356

m.40419

AAEL007035

CPIJ006370

3.82e-62

Complete; dual specificity kinase

tak1 (MAP3K)

GAWM01012184

m.47419

AAEL012659

CPIJ006370

8.20e-54

Complete; dual specificity kinase

I-Kappa-B Kinase 2 (IKK2, IKK-gamma), key/kenny

GAWM01018250

m.843

AAEL012510

CPIJ006917

2.02e-43

Complete; NEMO and UBAN motifs

I-Kappa-B Kinase 1 (IKK1, IKK-beta), ird5

GAWM01013537

m.5295

AAEL003245

CPIJ015672

0

Complete; kinase domain present

Transcription

      

NF-kappaB transcription factor, Relish

GAWM01014884

m.58438

AAEL007624

CPIJ012236

5.09e-52

Complete; NF-kB/Relish; rel homology domain (RHD), IPT domain, ankyrin repeat domain, death-like domain.

NF-kappaB transcription factor, Relish

GAWM01014885

m.58439

AAEL007624

CPIJ012236

2.64e-27

Partial; possibly Rel-2 or truncated isoform; RHD only

AMPs

      

Attacin-like AMP

GAWM01008443

m.3410

n/a

n/a

3.53e-07

Attacin-like AMP,one glycine-rich G domain (AA 56–115); no signal peptide

Attacin

GAWM01017969

m.7821

AAEL003389

n/a

1.39e-22

Complete; two glycine-rich domains (AA 75–191); signal peptide (AA 1–18)

Defensin

GAWM01019039

m.9997

n/a

n/a

1.46e-04

Complete and probable paralog; 6 cysteines present; signal AA 1-22

Defensin

GAWM01019040

m.9998

n/a

n/a

5.14e-08

Complete and probable paralog; 6 cysteines present; signal AA 1-21

Cecropin

GAWM01000005

m.10000

n/a

n/a

3.93e-14

Complete; cecropin family signature sequence AA 31–54; signal AA 1-23

Regulators

      

Caudal homeobox protein

GAWM01004228

m.2158

AAEL014557

CPIJ802291

1.83e-82

Homeobox domain present

Poor imd response upon knock-in (PIRK); PIMS; RUDRA

GAWM01010231

m.4008

n/a

CPIJ014088

3.27e-09

Putative, needs functional confirmation

FAS-associated factor 1, caspar

GAWM01012793

m.49687

AAEL003579

CPIJ012219

0

Complete; has FAF1, UAS and UBS domains

Peptidoglycan Recognition Protein (Short form); PGRPSC2/SC3

GAWM01018647

m.9236

AAEL007039

CPIJ016770

4.37e-84

Complete; Short form PGRP domain, signal AA 1-16

  1. aTM, transmembrane helix; AA, amino acids; BIR, baculovirus IAP repeat; NEMO, NF-kappaB essential modulator; UBAN, ubiquitin binding motif; AMP, antimicrobial peptide.