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Table 6 Percentage of households free of fleas or ticks

From: A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto™ (fluralaner) against Frontline™ (fipronil) in flea- and tick-infested dogs

  Bravecto™ (fluralaner) Frontline™ (fipronil) p value Lower 97.5% 1-sided C.I.a
Fleas     
 Week 2 89.57% 62.30% <0.0001 0.1498
 Week 4 94.87% 63.93% <0.0001 0.1916
 Week 8 95.65% 70.49% <0.0001 0.1416
 Week 12 97.39% 81.97% <0.0001 0.0586
Ticks     
 Week 2 97.67% 89.47% 0.0006 -0.0575
 Week 4 97.67% 84.21% 0.0001 -0.0175
 Week 8 97.67% 94.74% 0.0024 -0.0953
 Week 12 100.0% 100.0% n/ab n/ab
  1. aResult greater than -0.15 required to declare significant non-inferiority. Result greater than 0 required to declare significant one-sided superiority with α = 0.025.
  2. bNo statistical test as all households were free of ticks at week 12.
  3. n/a: not applicable.