Table 2 Fluralaner pharmacokinetic parameters following oral administration (25 mg/kg) to fasted or fed dogs
From: The effect of food on the pharmacokinetics of oral fluralaner in dogs
Parameter | Unit | Fasted group | Fed group | P value | Ratio (fed/fasted) |
|---|---|---|---|---|---|
Mean ± SD | Mean ± SD | ||||
(range) | (range) | ||||
Cmax | (ng/mL) | 1591 ± 708 | 3377 ± 669 | 0.0015 | 2.1 |
(1037–2683) | (2325 – 4326) | ||||
tmax | (day) | 1.3 ± 1.2 | 1.4 ± 1.3 | 0.8096 | - |
(0.17 – 3.00) | (0.33 – 4.00) | ||||
AUC0-91d | (day*ng/mL) | 31369 ± 20654 | 78785 ± 11440 | 0.0022 | 2.5 |
(14316 – 63557) | (60862 – 91854) |