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Table 1 Plasma pharmacokinetic parameters of fluralaner in dogs after either single oral or single i.v. administration

From: Pharmacokinetics of fluralaner in dogs following a single oral or intravenous administration

Parameters Oral 12.5 mg/kg n = 6 Oral 25.0 mg/kg n = 6 Oral 50.0 mg/kg n = 6 Intravenous 12.5 mg/kg n = 6
Cmax (ng/mL) 2144 ± 860 3948 ± 1734 5419 ± 2086 7109 ± 908
tmaxa (day) 1 (range 0.08–2) 1 (range 1–2) 1 (range 0.17–3) n/a
AUC(0-d112) (day* ng/mL) 29665 ± 13858 46115 ± 18932 70171 ± 26412 87198 ± 11835
AUC(0→∞) (day*ng/mL) 29922 ± 13808 46416 ± 18929 70531 ± 26529 87779 ± 12004
t1/2 (day) 13 ± 1 12 ± 3 14 ± 1 15 ± 2
MRT (day) 19 ± 2 15 ± 4 17 ± 3 20 ± 3
Cl (L/kg/day) n/a n/a n/a 0.14 ± 0.02
Vz (L/kg) n/a n/a n/a 3.1 ± 0.5
  1. aMedian, other values are mean ± standard deviation.
  2. n/a - not applicable.