From: Pharmacokinetics of fluralaner in dogs following a single oral or intravenous administration
Parameters | Oral 12.5 mg/kg n = 6 | Oral 25.0 mg/kg n = 6 | Oral 50.0 mg/kg n = 6 | Intravenous 12.5 mg/kg n = 6 |
---|---|---|---|---|
Cmax (ng/mL) | 2144 ± 860 | 3948 ± 1734 | 5419 ± 2086 | 7109 ± 908 |
tmaxa (day) | 1 (range 0.08–2) | 1 (range 1–2) | 1 (range 0.17–3) | n/a |
AUC(0-d112) (day* ng/mL) | 29665 ± 13858 | 46115 ± 18932 | 70171 ± 26412 | 87198 ± 11835 |
AUC(0→∞) (day*ng/mL) | 29922 ± 13808 | 46416 ± 18929 | 70531 ± 26529 | 87779 ± 12004 |
t1/2 (day) | 13 ± 1 | 12 ± 3 | 14 ± 1 | 15 ± 2 |
MRT (day) | 19 ± 2 | 15 ± 4 | 17 ± 3 | 20 ± 3 |
Cl (L/kg/day) | n/a | n/a | n/a | 0.14 ± 0.02 |
Vz (L/kg) | n/a | n/a | n/a | 3.1 ± 0.5 |