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Table 1 Plasma pharmacokinetic parameters of fluralaner in dogs after either single oral or single i.v. administration

From: Pharmacokinetics of fluralaner in dogs following a single oral or intravenous administration

Parameters

Oral 12.5 mg/kg n = 6

Oral 25.0 mg/kg n = 6

Oral 50.0 mg/kg n = 6

Intravenous 12.5 mg/kg n = 6

Cmax (ng/mL)

2144 ± 860

3948 ± 1734

5419 ± 2086

7109 ± 908

tmaxa (day)

1 (range 0.08–2)

1 (range 1–2)

1 (range 0.17–3)

n/a

AUC(0-d112) (day* ng/mL)

29665 ± 13858

46115 ± 18932

70171 ± 26412

87198 ± 11835

AUC(0→∞) (day*ng/mL)

29922 ± 13808

46416 ± 18929

70531 ± 26529

87779 ± 12004

t1/2 (day)

13 ± 1

12 ± 3

14 ± 1

15 ± 2

MRT (day)

19 ± 2

15 ± 4

17 ± 3

20 ± 3

Cl (L/kg/day)

n/a

n/a

n/a

0.14 ± 0.02

Vz (L/kg)

n/a

n/a

n/a

3.1 ± 0.5

  1. aMedian, other values are mean ± standard deviation.
  2. n/a - not applicable.