Table 5 Clinical findings in dogs of treated and control groups following the first treatment
Observation | Number of dogs affected | Analysis | Conclusion |
|---|---|---|---|
Scattered incidences of abnormal feces (loose, mucoid, traces of fresh blood) | Total observed: n = 15 | Similar number of animals affected in each treated group compared to controls; abnormal feces already observed pre-treatment across all groups | Not treatment related, no adverse event |
Control group: n = 4 | |||
1X group: n = 5 | |||
3X group: n = 3 | |||
5X group: n = 3 | |||
Reduced body condition score (2 or 2–3 on a scale of 1–5) | Total observed: n = 8 | Similar (3X group, 5X group) or lower (1X group) number of animals affected compared to controls; no dose–response relationship | Not treatment related, no adverse event |
Control group: n = 3 | |||
1X group: n = 0 | |||
3X group: n = 3 | |||
5X group: n = 2 | |||
Localized hair thinning/pressure wound/wound | Total observed: n = 6 | Similar (1X group, 5X group) or lower (3X group) number of animals affected compared to controls; no dose–response relationship | Not treatment related, no adverse event |
Control group: n = 2 | |||
1X group: n = 3 | |||
3X group: n = 0 | |||
5X group: n = 1 | |||
Vomiting of food after first treatment, no other clinical findings | Total observed: n = 1 | Single case; no dose–response relationship; not observed following repeated treatment | Not treatment related, no adverse event |
Control group: n = 0 | |||
1X group: n = 1 | |||
3X group: n = 0 | |||
5X group: n = 0 | |||
Gastroenteritis with inappetence, dullness, vomit | Total observed: n = 1 | Single case; no dose–response relationship; not observed following repeated treatment | Not treatment related, no adverse event |
Control group: n = 0 | |||
1X group: n = 0 | |||
3X group: n = 1 | |||
5X group: n = 0 |