Figure 2

Comparative microfilaricidal activity of IVM against Brugia in WT versus SCID mice. Bm mf densities in peripheral circulating blood (A) or cardiac circulation (B) at `baseline’ (48 h following intravenous perfusion with 1.25 × 10⁵ purified mf) or at indicated time points following treatment with 5 mg/kg ivermectin (IVM) or vehicle control (VC) via the intraperitoneal route. Top panels are data derived from WT BALB/c, bottom panels are data from BALB/c SCID mice. Error bars indicate median mf densities and interquartile range. Data is from an individual experiment (n = 4/group). Significant differences with time (paired T Test) or between groups (Mann Whitney Test) are indicated *P < 0.05.