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Figure 6 | Parasites & Vectors

Figure 6

From: Antihistamine response: a dynamically refined function at the host-tick interface

Figure 6

Positions of other histamine-binding sites and alignment of the tick Ra-HBP2 (PDB: 1QFT) and the butterfly BBP (PDB: 1BBP). The representative predicted positions (A) for the third histamine-binding site (encircled yellow) while bound to the first (red) and second histamine (blue) to the Ra-HBP2 (color-coded from N-terminus (blue) to C-terminus (red)). The positions of the third histamine are within ~12 Å distance from each other - this is also the same span of exploration represented in the encircled cluster of Figure 5. The pairwise alignment (B) shows positions of the α-helices and β-hairpin loops of the Ra-HBP2 (boxed) in relation the BBP. Boxes of different color (i.e., red, black, yellow and blue) correspond to the same colors indicated in Figure 2D. Asp residues within the loop regions are in magenta. The (.) denotes similar residues and the (*) denote identical residues.

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