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Table 1 Monthly parasitological monitoring

From: Establishment of macrocyclic lactone resistant Dirofilaria immitis isolates in experimentally infected laboratory dogs

Name DOI Date 26Oct12 27Nov12 20Dec12 18Jan13 18Feb13 15Mar13 19Apr13 17May13 14Jun13 12Jul13 14Aug13 13Sep13 7Nov13 9Dec13 10Jan14
LSU10a 23-Mar-12 Occult + + + + + + + + + + + + + + +
   DS 0 3 7 1 12 8 21 12 10 14 1 ND 6 7 ND
   Knotts 7 36 345 516 869 684 130 1438 615 1342 8 ND ND ND 2
LSU10b 23-Mar-12 Occult + + + + + + + + + + + + + + +
   DS 6 9 100 26 74 33 443 ND 631 640 621 ND 317 79 ND
   Knotts 526 848 2610 196 374 1723 9460 9020 8294 16082 ND ND ND ND ND
   DPI 218 250 273 302 333 358 393 421 449 477 510 540 595 627 659
LSU13a 15-Jun-12 Occult - + + + + + + + + + + + + + +
   DS 0 0 0 1 27 22 307 ND 543 562 767 ND 315 145 ND
   Knotts 0 0 2 104 1222 1723 6878 7810 8767 12254 ND ND ND ND ND
LSU13b 15-Jun-12 Occult - + + + + + + + + + + + + + +
   DS 0 0 0 1 52 26 263 ND 817 89 1047 ND 536 300 ND
   Knotts 0 0 5 76 3480 1672 5222 11770 19019 21516 3256 ND ND ND ND
   DPI 134 166 189 218 249 274 309 337 365 393 426 456 511 543 575
LSU10-II 22-Feb-13 Occult       - - - - - - + + + +
   DS       0 0 0 0 0 0 ND 5 13 ND
   Knotts       0 0 0 0 0 0 ND ND ND 1019
   DPI N/A N/A N/A N/A N/A 22 57 85 113 141 174 204 259 291 323
  1. Bold, italicized values indicate first detection of circulating Mf DOI, Date of Infection; Occult, Adult Heartworm Antigen Test; DS, Direct Smear using 20 μL of whole blood; Knotts, Modified Knott’s Technique; DPI, Days Post-Infection; ND, No Data.