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Table 2 Cytotoxicity and anti-MAYV activity of EtOAc, n-BuOH and EtOAc-Pp fractions

From: Anti-Mayaro virus activity of Cassia australis extracts (Fabaceae, Leguminosae)

Substance CC50(μg/mL)a CC90(μg/mL)a IC50(μg/mL)b IC90(μg/mL)b SIc RPd
n-BuOH 2614 ± 366 821 ± 115 7,1 ± 1,0 40,9 ± 5,7 20 10
EtOAc 457,7 ± 9,5 176,1 ± 3,5 8,2 ± 0,2 89,1 ± 4,4 2 1
EtOAc-Pp 324,1 ± 6,5 154,7 ± 3,1 2,5 ± 0,1 4,7 ± 0,3 33 16,5
ribavirin 523,1 ± 42,5 215,4 ± 6,2 62,3 ± 4,4 112,4 ± 8,2 2 nd
  1. a50% and 90% cytotoxic concentration.
  2. b50% and 90% inhibitory concentration of viral replication.
  3. cSelectivity Index = standard IC90/substance IC90.
  4. dRelative Potency = ratio between ribavirin (reference substance) IC90 and the tested substance’s IC90.
  5. nd – Not determined.