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Table 2 Cytotoxicity and anti-MAYV activity of EtOAc, n-BuOH and EtOAc-Pp fractions

From: Anti-Mayaro virus activity of Cassia australis extracts (Fabaceae, Leguminosae)

Substance

CC50(μg/mL)a

CC90(μg/mL)a

IC50(μg/mL)b

IC90(μg/mL)b

SIc

RPd

n-BuOH

2614 ± 366

821 ± 115

7,1 ± 1,0

40,9 ± 5,7

20

10

EtOAc

457,7 ± 9,5

176,1 ± 3,5

8,2 ± 0,2

89,1 ± 4,4

2

1

EtOAc-Pp

324,1 ± 6,5

154,7 ± 3,1

2,5 ± 0,1

4,7 ± 0,3

33

16,5

ribavirin

523,1 ± 42,5

215,4 ± 6,2

62,3 ± 4,4

112,4 ± 8,2

2

nd

  1. a50% and 90% cytotoxic concentration.
  2. b50% and 90% inhibitory concentration of viral replication.
  3. cSelectivity Index = standard IC90/substance IC90.
  4. dRelative Potency = ratio between ribavirin (reference substance) IC90 and the tested substance’s IC90.
  5. nd – Not determined.
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Parasites & Vectors

ISSN: 1756-3305

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