IgG antibody response to the An. gambiae cE5 and gSG6 proteins. Comparison of the anti-cE5 and anti-gSG6 IgG responses among exposed individuals during the malaria transmission season (survey Aug 1994, n = 207, average age ±95% CI = 22.7 ± 16.9). (A) Box plots of OD values among responders to both cE5 and gSG6 antigens (n = 156). Boxes display median values, 25th and 75th percentiles. Whiskers represent 5–95 percentiles and dots the outliers. The IgG response to the cE5 protein in non-exposed individuals (n = 59, average age ±95% CI = 26.3 ± 16.1) is shown as control (C). IgG levels are expressed as OD492. P value determined by the Wilcoxon matched-pairs signed rank test (****, p < 0.0001). (B) Seroprevalence of anti-cE5 and anti-gSG6 IgG antibodies. Error bars indicate 95% confidence intervals. P value determined by Fisher’s exact test (****, p < 0.0001).