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Table 4 Outcomes of liver function tests for mice from the uninfected control, untreated control and treated groups MBZ-1% tragacanth and MBZ-OS (10 mice per group)

From: An alternative mebendazole formulation for cystic echinococcosis: the treatment efficacy, pharmacokinetics and safety in mice

Parameters

Definitions

Units

Uninfected control

Untreated control

MBZ-1% tracangth

MBZ-OS

T-BIL

Total bilirubin

umol/L

2.3 (0.8)

2.8 (0.4)

3.2* (0.8)

2.9 (0.5)

D-BIL

Direct bilirubin

umol/L

0.5 (0.3)

0.3 (0.1)

0.4 (0.2)

0.3 (0.1)

I-BIL

Indirect bilirubin

umol/L

1.8** (0.7)

2.6* (0.4)

2.8* (0.7)

2.6* (0.5)

TP

Total protein

g/L

55.2 (1.9)

57.7 (2.9)

58.2 (3.8)

63.1** (3.2)

ALB

Albumin

g/L

31.6 (1.7)

32.2 (1.6)

32.7 (2.0)

34.8 (2.0)

GLB

Globulin

g/L

23.6 (0.8)

25.6 (3.3)

25.5 (3.0)

28.3** (2.4)

A/G

  

1.3 (0.1)

1.3 (0.2)

1.3 (0.2)

1.2 (0.4)

AST

Aspartate transaminase

U/L

122.8** (32.1)

173.7* (107.0)

113.9** (16.9)

100.8** (14.7)

ALT

Alanine transaminase

U/L

45.1** (21.8)

81.0* (48.8)

35.7 ** (17.7)

27.6 ** (4.5)

AST/ALT

  

3.0 (0.8)

2.3 (0.7)

3.6 ** (1.2)

3.7** (0.7)

ALP

Alkaline phosphatase

U/L

86.2 (29.6)

67.4 (14.0)

74.5 (28.8)

80.7 (19.1)

  1. *P < 0.05 vs. uninfected group.
  2. **P < 0.05 vs. untreated control group.