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Figure 6 | Parasites & Vectors

Figure 6

From: Sm16, a major component of Schistosoma mansoni cercarial excretory/secretory products, prevents macrophage classical activation and delays antigen processing

Figure 6

Recombinant Sm16 delays antigen processing by BMMΦs. BMMΦs were exposed for 10, 30, 100 or 1000 min to AlexaFluor®488 conjugated E. coli BioParticles® (100 particles per cell) in the absence (Media, open circles), or presence of rSm16 (10 μg/ml) (closed circles). (A) Representative flow plots of BMMΦs 30 min after exposure to E. coli particles. (B) Mean percentages ± SEM of BMMΦs containing labelled E. coli BioParticles at each time point, and (C) representative overlaid histograms including the MFI ± SD of each group. (D) Mean ± SEM fold-retention of labelled E. coli BioParticles within rSm16-treated BMMφs, relative to the respective MFI of BMMΦs treated with Media control, arbitrarily set to 1. Statistically significant differences between the means of rSm16 treated and Media controls at each time point were examined by ANOVA and Sidak’s test (** = p < 0.01; **** = p < 0.0001).

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Parasites & Vectors

ISSN: 1756-3305

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