Figure 5

Comparative effects of pharmacological inhibition on motility. A-C) Pharmacological inhibition of three putative targets via available chemical inhibitors leads to correlative motility phenotype in free-living (G. tigrina) and parasitic flatworms (S. mansoni). Chemical inhibitors of ARPC2 (A) and SDH1 (B) caused a dose-dependent decrease in motility in both species as measured by contractions per second (schistosomula) or millimeters of translational movement per second (planaria). Chemical inhibitor of NDUFV2 (C) did not have any dose-dependent effects in either organism. Nonlinear regression is fit to a four-parameter variable slope model; log(inhibitor) vs. response. Bars represent SEM from the combination of two experiments.