Table 4 Laboratory abnormal findings in ehrlichiosis caused by Ehrlichia canis and anaplasmosis caused by Anaplasma platys and Anaplasma phagocytophilum
From: Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe
Clinical disease | Species | Laboratory abnormal findings |
|---|---|---|
Canine monocytyc ehrlichiosis | E. canis | • Mild to moderate normocytic normochromic non regenerative anemia |
• Neutropenia | ||
• Neutrophilia | ||
• Lymphopenia | ||
• Monocytosis | ||
• Granular lymphocytosis (uncommon) | ||
• Thrombocytopenia | ||
• Thrombocytopathy | ||
• Pancytopenia: medullary hypoplasia or aplasia (chronic forms, 15-20% of clinical cases) | ||
• Hyperproteinemia | ||
• Hyperglobulinemia | ||
• Hypergammaglobulinemia, usually polyclonal | ||
• Hypoalbuminemia | ||
• Proteinuria | ||
• Renal azotemia | ||
• Mild increase in hepatic enzymes (ALT, ALP) | ||
• Mononuclear or neutrophilic pleocytosis | ||
Canine granulocytic anaplasmosis | A. phagocytophilum | • Non regenerative mild to moderate normocytic normochromic anemia |
• Regenerative anemia (rare) | ||
• Lymphopenia | ||
• Neutropenia, neutrophilia (sometimes left shift) or normal neutrophil concentration | ||
• Thrombocytopenia | ||
• Hyperglobulinemia | ||
• Hypoalbuminemia | ||
• Increased ALP | ||
• Mild hyperbilirubinemia | ||
• Neutrophilic inflammation in synovial fluid | ||
• Sometimes direct Coombs’ test/platelet-bound antibody test positive | ||
Canine thrombocytotrophic anaplasmosis | A. platys | • Thrombocytopenia |
• Non regenerative mild to moderate normocytic normochromic anemia | ||
• Hyperglobulinemia | ||
• Hypoalbuminemia |