Figure 1

S. japonicum infection results in an exacerbated liver granulomatous inflammation in AQP4 KO mice. At 0,3, 5,8 weeks post-infection, four AQP4 WT or KO mice were randomly chosen and sacrificed. Liver sections were stained with HE for microscopic examination. (A) Histopathology in the livers (magnification: 100×). Results are representative of two independent experiments. (B) Sizes of the granulomas were measured by computer-assisted morphometric analysis. (C) Absolute numbers of neutrophils, eosinophils, lymphocytes and macrophages in the granulomas. Values are given as mean ± SD of 8 AQP4 WT or KO mice from two independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001.