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Table 3 The profile of a new-positive SNAP test result for Borrelia burgdorferi infection, including preventative fraction and risk ratio assessment among incompletely and completely vaccinated dogs

From: Immunization with a recombinant subunit OspA vaccine markedly impacts the rate of newly acquired Borrelia burgdorferi infections in client-owned dogs living in a coastal community in Maine, USA

 

2009

2010

2011

2012

2013

Percent (+) of all tests run

12.22%

15.45%

12.30%

13.70%

13.70%

NEW (+) as % of all tests run

5.90%

7.86%

5.60%

7.01%

6.10%

Profile of a NEW (+) out of ALL new (+)’s

     

Incomplete-vaccination

86.59% (71/82)

89.52% (94/105)

85.92% (61/71)

86.08% (68/79)

95.45% (63/66)

Full-vaccination

13.41% (11/82)

10.48% (11/105)

14.08% (10/71)

13.92% (11/79)

4.55% (3/66)

Infection rate (IR) based on vaccine status*:

     

ALL incomplete-vaccination

16.86% (71/421)

32.08% (94/293)

18.32% (61/333)

23.13% (68/294)

20.32% (63/310)

Complete-vaccination

1.13% (11/970)

1.04% (11/1053)

1.07% (10/933)

1.32% (11/833)

0.39% (3/762)

Negative infection rate based on vaccine status

     

ALL incomplete-vaccination

83.14% (350/421)

67.92% (199/293)

81.68% (272/333)

76.87% (226/294)

79.68% (247/310)

Complete-vaccination

98.87% (959/970)

98.96% (1042/1053)

98.93% (923/933)

98.68% (822/833)

99.61% (759/762)

Chi-square test statistic

130.95

307.01

137.89

158.56

151.47

P-value

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

Preventative fraction (PF) against infection**

93.29%

96.76%

94.16%

94.29%

98.08%

Risk ratio (RR)***

14.92

30.85

17.12

17.52

52.10

  1. *Infection Rate = No. positive in vaccine status category/all dogs tested in that category. NOTE: All dogs other than those testing New (+) had (−) tests.
  2. **PF = [(Incidence of Event in Untreated – Incidence of Event in Treated)/Incidence of Event in Untreated] × 100.
  3. ***Risk Ratio = % Infected when incompletely vaccinated/% infected when completely vaccinated.