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Table 1 Geometric mean adult flea ( Ctenocephalides felis) counts and percent efficacy relative to non-treated controls for dogs treated with a topical spot-on formulation of fipronil and permethrin

From: Efficacy of a new combination of fipronil and permethrin against Ctenocephalides felis flea infestation in dogs

Water exposure study days No water exposure 2 or 3 water immersions (on D10, and 24, or on D10, D17 and 24, respectively) 1 shampooing (on D17)
Study 1 1 Study 2 2 Study 3 2 Study 4 2 Study 5 2
Flea counts Efficacy (%) Flea counts Efficacy (%) Flea counts Efficacy (%) Flea counts Efficacy (%) Flea counts Efficacy (%)
Control group 3 Treated group 3 Control group 3 Treated group 3 Control group 3 Treated group 3 Control group 3 Treated group 3 Control group 3 Treated group 3
(n = 8) (n = 8) (n = 8) (n = 8) (n = 8) (n = 8) (n = 8) (n = 8) (n = 8) (n = 8)
D1-2 55.3 0.44 99.3 67.2 0.74 99.0 62.0 0.04 100.0 74.3 0.04 100.0 67.4 0.34 99.5
D8-9 79.4 0.04 100 55.4 0.04 100.0 79.4 0.04 100.0 86.9 0.04 100.0 59.9 0.04 100.0
D15-16 84.9 0.04 100 64.9 0.04 100.0 78.9 0.04 100.0 85.9 0.04 100.0 63.2 0.14 99.9
D22-23 86.8 0.24 99.8 68.0 0.04 100.0 87.2 0.04 100.0 97.9 0.04 100.0 73.4 0.04 100.0
D29-30 89.3 1.44 98.4 62.0 0.04 100.0 82.0 0.04 100.0 89.8 0.04 100.0 67.1 0.34 99.6
  1. 1In study 1, fleas were counted and removed 24 h after treatment or infestation.
  2. 2In studies 2, 3,4 and 5, fleas were counted and removed 48 h after treatment or infestation.
  3. 3Geometric mean flea count.
  4. 4Treated group differed statistically significantly (p < 0.005) from the untreated Control group.