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Table 1 Prescribed preventive, administration route, compliance, doxycycline use, and results of modified Knott test and antigen tests on samples collected from 15 heartworm infected dogs managed with slow kill

From: False negative antigen tests in dogs infected with heartworm and placed on macrocyclic lactone preventives

Dog ID Preventive prescribed Route of administration Compliant with dispensing Doxycycline (10 mg/kg PO) protocol Modified Knott Pre-heating antigen test results Post-heating antigen test results
1 Moxidectin Topical No 30d ND - +
2 Moxidectin Topical Yes 30d, four times ND - +
3 Moxidectin Topical No 30d, four times ND - +
4 Ivermectin Oral Yes 30d, twice Neg - +
5 Ivermectin Oral No 30d Neg - +
6 Ivermectin Oral No 30d, twice Neg - +
7 Ivermectin Oral Yes 30d, twice Neg - +
8 Ivermectin Oral No 30d POS* - +
9 Moxidectin Topical Yes 6mo ND - -
10 Moxidectin Topical No 30d, twice Neg - -
11 Ivermectin Oral Yes 30d Neg - -
12 Ivermectin Oral Yes 30d, twice Neg - -
13 Ivermectin Oral No 30d ND - -
14 Ivermectin, Oral Yes 30d, twice ND - -
  Milbemycin Oral      
15 Ivermectin, Oral No 30d, three times Neg - -
  Milbemycin Oral      
  1. *Identity of microfilariae confirmed as Dirofilaria immitis by morphology and by PCR and sequencing.
  2. ND = Not Done.