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Table 1 Overrepresented Gene ontology (GO) terms for up- (↑) and down- regulated (↓) genes in infected liver

From: Transcriptional analysis identifies key genes involved in metabolism, fibrosis/tissue repair and the immune response against Fasciola hepatica in sheep liver

Major Function

Transcription

p-value *

Oxidoreductase activity

cholesterol 7-alpha-monooxygenase activity (GO:0008123)

↓

0.0017

flavin-containing monooxygenase activity (GO:0004499)

↓

0.0086

leukotriene-B4 20-monooxygenase activity (GO:0050051)

↓

0.0069

arachidonic acid 11 12-epoxygenase activity (GO:0008405)

↓

0.0017

arachidonic acid 14 15-epoxygenase activity (GO:0008404)

↓

0.0017

alkane 1-monooxygenase activity (GO:0018685)

↓

0.0086

linoleic acid epoxygenase activity (GO:0071614)

↓

0.0017

Immune system

neutrophil aggregation (GO:0070488)

↑

0.0007

neutrophil chemotaxis (GO:0030593)

↑

0.0004

regulation of T-helper 2 cell differentiation (GO:0045628)

↑

0.0015

regulation of B cell activation (GO:0050864)

↑

0.0007

negative regulation of B cell apoptosis (GO:0002903)

↑

0.0015

cellular response to type I interferon (GO:0071357)

↓

0.0017

positive regulation of interferon-alpha production (GO:0032727)

↓

0.0001

positive regulation of interferon-beta production (GO:0032728)

↓

0.0006

regulation of type III interferon production (GO:0034344)

↓

0.00001

Extracellular matrix

collagen type I (GO:0005584)

↑

0.0007

proteinaceous extracellular matrix (GO:0005578)

↑

0.0002

extracellular matrix (GO:0031012)

↑

0.0007

  1. *p-value < 0.05.
  2. Analysis revealed GO terms related with oxidoreductase (‘molecular function’), immune system (‘biological processes’) and extra cellular matrix (‘cellular component’).
  3. Full list of GO analyses can be seen in Additional file 3.