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Table 1 DNA vaccines containing Trypanosoma cruzi genes for prophylactic use

From: Prophylactic and therapeutic DNA vaccines against Chagas disease

Vector

Model

Immune Response

Survival (%)

Recombinant antigen

Reference

pCMVI.UBF3/2

C57BL/6

Th1

30-60

ASP-1, ASP-2 and TSA-1

29

pcDNA3

BALB/c

Th1

100

Clone 9 (ASP-2)

30

pCMV

BALB/c

ND

25-100

TSSA

31

C57BL/6

pcDNA3

BALB/c

Th1

ND

catalytic domain of a trans-sialidase

32

pcDNA3.1

C57BL/6

Th1

ND

TcG1, TcG2 and TcG4

33

pBK-CMV

BALB/c

Th1/Th2

92

TcSP

35

pBK-CMV

BALB/c

Th1

75

TcSSP4

36

pBK-CMV

Beagle dogs

Th1

100

TcSP, TcSSP4

37

pSCREEN

BALB/c

Th1

ND

Cruzipain

40

pcDNA3

C3H/HeN

Th1

100

Cruzipain

41

pCMV

C57BL/6J

Th1

80

LYT1

42

Vaccinia Virus

BALB/c

Th1

25-50

ANYNFTLV epitope

43

pcDNA3.1

BALB/c

ND

70

Tc13

44

pCMV4

BALB/c and C57BL/6 transgenic mice

Th1

75

PFR2 and PFR3

45

pcDNA3.1

Holtzman rats

Th1/Th2

ND

CCL4/MIP-1 beta chemokine

46

  1. ND = Not determined.