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Table 1 DNA vaccines containing Trypanosoma cruzi genes for prophylactic use

From: Prophylactic and therapeutic DNA vaccines against Chagas disease

Vector Model Immune Response Survival (%) Recombinant antigen Reference
pCMVI.UBF3/2 C57BL/6 Th1 30-60 ASP-1, ASP-2 and TSA-1 29
pcDNA3 BALB/c Th1 100 Clone 9 (ASP-2) 30
pCMV BALB/c ND 25-100 TSSA 31
C57BL/6
pcDNA3 BALB/c Th1 ND catalytic domain of a trans-sialidase 32
pcDNA3.1 C57BL/6 Th1 ND TcG1, TcG2 and TcG4 33
pBK-CMV BALB/c Th1/Th2 92 TcSP 35
pBK-CMV BALB/c Th1 75 TcSSP4 36
pBK-CMV Beagle dogs Th1 100 TcSP, TcSSP4 37
pSCREEN BALB/c Th1 ND Cruzipain 40
pcDNA3 C3H/HeN Th1 100 Cruzipain 41
pCMV C57BL/6J Th1 80 LYT1 42
Vaccinia Virus BALB/c Th1 25-50 ANYNFTLV epitope 43
pcDNA3.1 BALB/c ND 70 Tc13 44
pCMV4 BALB/c and C57BL/6 transgenic mice Th1 75 PFR2 and PFR3 45
pcDNA3.1 Holtzman rats Th1/Th2 ND CCL4/MIP-1 beta chemokine 46
  1. ND = Not determined.