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Table 1 Geometric mean reductions in Demodex spp. mite counts of dogs treated once orally with Bravecto or topically on three occasions at 28-day intervals with Advocate®

From: Efficacy of orally administered fluralaner (BravectoTM) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs

Study days Study groups Bravecto Advocate® p-value
−4 Meana mite counts (n) 447.0 509.4/478.6b Nac
Count range (n) 41-1740 79-2724
28 Meana mite counts (n) 0.8 10.0  
Count range (n) 0-14 0-496  
Efficacy (%) 99.8 98.0 0.0917
56 Meana mite counts (n) 0.0 18.5  
Count range (n) Nac 0-115  
Efficacy (%) 100.0 96.4 <0.0001
84 Meana mite counts (n) 0.0 25.6  
Count range (n) Nac 0-286  
Efficacy (%) 100.0 94.7 0.0020
  1. aGeometric mean.
  2. bMite counts calculated without one dog, which was euthanized on Day 59.
  3. cNot applicable.