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Table 3 Crude and adjusted incidence rates of general practitioner consultations for tick bites and Lyme borreliosis diagnoses per 100,000 inhabitants, and national estimates of the total numbers among the 16.6 million inhabitants of the Netherlands in 2010

From: Physician reported incidence of early and late Lyme borreliosis

  Incidence (95% CI) per 100,000 National numbers
Crude estimations     
Tick bites 494.7 (478.1-511.8) 81,997 (79,253 – 84,827)
Erythema migrans 131.5 (127.1-136.0) 21,802 (21,064 – 22,545)
Disseminated Lyme borreliosis* 13.6 (12.7-14.5) 2,250 (2,103 – 2,400)
Persisting symptoms attributed to Lyme borreliosis** 13.7 (12.7-14.6) 2,263 (2,112 – 2,416)
Adjusted estimations***     
Disseminated Lyme borreliosis* 7.7 (7.2-8.2) 1,268 (1,186-1,353)
Persisting symptoms attributed to Lyme borreliosis** 5.5 (5.1-5.8) 905 (845–966)
Target period adjusted estimations****   
Disseminated Lyme borreliosis* 8.4 (7.8-8.9) 1,386 (1,296-1,479)
Persisting symptoms attributed to Lyme borreliosis** 6.9 (6.4-7.3) 1,137 (1,061-1,214)
  1. 95%CI, 95% confidence interval.
  2. *“Disseminated Lyme borreliosis” includes: borrelial lymphocytoma, acrodermatitis chronica atrophicans, Lyme neuroborreliosis, Lyme arthritis, Lyme carditis, ocular manifestations.
  3. **“Persisting symptoms attributed to Lyme borreliosis” includes: encephalopathy, persisting symptoms after treatment for Lyme borreliosis with or without active Borrelia infection.
  4. ***Primary adjustment scenario:
  5. The incidence for disseminated Lyme borreliosis was adjusted according to the proportion of very likely diagnosis, and to the proportion of GP reports within the targeted period of diagnosis 2009 and 2010 (see Table 2).
  6. The incidence for persisting symptoms attributed to Lyme borreliosis was adjusted according to the proportion of likely diagnosis, and to the proportion of GP reports within the targeted period of diagnosis 2008 to 2010 (see Table 2).
  7. ****Target period adjustment scenario:
  8. The incidence for disseminated Lyme borreliosis was adjusted according to the proportion of very likely, likely, and possible diagnosis, and to the proportion of GP reports within the targeted period of diagnosis 2009 and 2010 (see Table 2).
  9. The incidence for persisting symptoms attributed to Lyme borreliosis was adjusted according to the proportion of likely diagnosis and possible diagnosis, and to the proportion of GP reports within the targeted period of diagnosis 2008 to 2010 (see Table 2).