Skip to main content
Figure 3 | Parasites & Vectors

Figure 3

From: Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals

Figure 3

Up-regulated IL-17A response in MF + individuals. Isolated PBMCs (2 x 105/well) from NEN (n = 12) or O. volvulus-infected MF+ (n = 164) or a-MF (n = 46) patients were stimulated with MSP-1 (0.25 μg/ml) for 72 hours. Thereafter, levels of IFN-γ (A) and IL-17A (B) were measured in the culture supernatants via ELISA. Data are plotted as fold increase over unstimulated controls. Graphs show box whiskers with median, interquartile ranges and outliers. Statistical significances between the indicated groups were obtained after Kruskal-Wallis and Mann–Whitney tests. (C) MSP-1 induced IFN-γ levels were correlated with the amount of ECP in plasma [20] and (D) MSP-1 induced IL-17 responses were correlated with the percentage of neutrophils [20]. Both correlations were tested for statistical significance using spearman correlation test.

Back to article page

Parasites & Vectors

ISSN: 1756-3305

Contact us