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Table 1 Regression analysis between MF + and a-MF patients

From: Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals

Parameter

Stimulus

Associations with univariable analysis

Multivariable analysis

 

C:A

MF/mg

MF +

IIT

IVM-12

 

IL-5

MSP-1

X

X

X

X

X

---

IL-13

MSP-1

X

X

X

X

X

---

IL-10

MSP-1

p = 0.0067

X

p = 0.0803

X

X

C:A (C↓A↑, p = 0.0067)

IL-6

MSP-1

p = 0.0016

X

X

X

X

nd

 

αCD3/αCD28

p = 0.0014

X

X

X

X

nd

TNF-α

MSP-1

p = 0.0050

X

p = 0.0224

p = 0.0523

p = 0.0296

C:A (C↓A↑, p = 0.0037)

 

αCD3/αCD28

p = 0.0025

X

X

X

X

nd

IL-17A

MSP-1

p = 0.0054

X

p = 0.0271

p = 0.0428*

p = 0.0377

C:A (C↓A↑, p = 0.0066)

IFN-γ

MSP-1

X

X

X

X

X

---

  1. *denotes negative correlation. 'nd' denotes that only one covariate was below p < 0.1 and therefore no multivariable analysis was done.'---' denotes no associated covariate.