Table 4 The correlative genes involved in the immune-relevant pathways from the results of KEGG pathway analysis in the six comparisons
Immune-relevant pathway | 3d vs. 0d | 30d vs. 0d | 60d vs. 0d | 30d vs. 3d | 60d vs. 3d | 60d vs.30d |
|---|---|---|---|---|---|---|
Hematopoietic cell lineage | CD59↓ | - | FCER2↑ | IL6R↑ | IL1R2↑, CD59↑ | - |
Complement and coagulation cascades | CD59↓, C5AR1↓ | - | - | C5AR1↑, C1R↑, CD59↑ | C5AR1↑, CD59↑ | - |
Toll-like receptor signaling pathway | IRF7↓, MAP3K7IP2↓, MAPK9↓ | IRAK1↑ | - | IRAK1↑, MAP3K7IP2↑, MAPK9↑, IRF7↑ | PIK3R2↑, MAPK9↑, IRF7↑ | - |
NOD-like receptor signaling pathway | SUGT1↓, MAP3K7IP2↓, MAPK9↓ | - | - | MAP3K7IP2↑, MAPK9↑, SUGT1↑ | MAPK9↑, SUGT1↑ | - |
RIG-I-like receptor signaling pathway | IRF7↓, LOC782671↓, MAPK9↓ | - | - | LOC782671↑, MAPK9↑, IRF7↑ | LOC782671↑, MAPK9↑, IRF7↑ | - |
Cytosolic DNA-sensing pathway | IRF7↓, LOC782671↓ | - | - | LOC782671↑, IRF7↑ | LOC782671↑, IRF7↑ | - |
Natural killer cell mediated cytotoxicity | FCER1G↓, PPP3R1↓ | SHC1↑ | - | PPP3R1↑, SHC1↑, FCER1G↑ | PIK3R2↑, NFATC1↑, PPP3R1↑, FCER1G↑ | SHC1↓ |
T cell receptor signaling pathway | PPP3R1↓, NCK2↑, PAK4↑ | PAK4↑ | - | NCK2↓, PPP3R1↑ | PAK4↓, NCK2↓, PIK3R2↑, NFATC1↑, PPP3R1↑ | - |
B cell receptor signaling pathway | PPP3R1↓ | - | - | PPP3R1↑ | PIK3R2↑, NFATC1↑, PPP3R1↑ | - |
Fc epsilon RI signaling pathway | FCER1G↓, MAPK9↓ | - | - | FCER1G↑, MAPK9↑ | PIK3R2↑, MAPK9↑, FCER1G↑ | - |
Leukocyte transendothelial migration | CYBA↓, CYBB↑, MSN↓, CTNNB1↓, MYL9↑ | - | - | CXCR4↓, MYL9↓, RHOH↓, CYBB↑ | MYL9↓, RHOH↓, PIK3R2↑, CYBB↓, CYBA↑ | - |
Intestinal immune network for IgA production | TGFB1↓, PIGR↑, TGFB2↑ | - | - | CXCR4↓, TGFB2↓, TGFB1↑ | TGFB2↓, TGFB1↑ | - |
Cemokine signaling pathway | FOXO3↓, GNB2↓, GSK3A↓ | SHC1↑, GSK3A↑ | GSK3A↑ | CXCR4↓, GNB2↑, FOXO3↑, GSK3A↑, SHC1↑ | GNG10↓, PIK3R2↑, GSK3A↑, FOXO3↑, GNB2↑ | SHC1↓ |
Fc gamma R-mediated phagocytosis | - | - | - | - | PIK3R2↑ | - |