Table 3 The prevalence and intensity of Schistosoma haematobium infections in children from six villages in the Niakhar study area in Central Senegal at baseline, 5 weeks post treatment and reinfection levels at 2 to 3 months after draining of ponds and backwater, relative to gender and age
Characteristics S. haematobium infection | |||||||
|---|---|---|---|---|---|---|---|
Gender | Age | ||||||
Variables | Female | Male | P-value | 5 - 7 years | 8 - 10 years | 11 - 15 years | P-value |
Baseline (June 2011) | |||||||
No. of children infected/examined | 91/142 | 150/187 | 88/141 | 85/105 | 68/83 | ||
Prevalence (95 % CI) | 64.1 % (55.9-71.5) | 80.2 % (73.9-85.3) | 0.001 | 62.4 % (54.2-69.9) | 80.9 % (72.4-87.3) | 81.9 % (62.3-88.7) | 0.001 |
Numbers of infected subject treated with PZQ | 91 | 146 | 88 | 83 | 66 | ||
GM egg count/10 ml of urine (95 % CI) | 177.0 (123.4-253.8) | 544.1 (421.4-702.6) | 0.001 | 238.9 (164.4-347.3) | 455.6 (313–662.9) | 438.7 (299.1-643.3) | <0.001 |
Treatment (August 2011) | |||||||
Follow-up efficacy of PZQ 5 weeks post treatment (in September 2011) | |||||||
No. of children infected/examined | 3/142 | 12/183 | 6/141 | 8/103 | 1/81 | ||
Prevalence (95 % CI) | 2.1 % (0.7-6) | 6.5 % (3.7-10.9) | 0.080 | 4.2 % (1.9-8.9) | 7.7 % (3.9-14.4) | 1.2 % (0.2-6.7) | 0.200 |
No. of infected treated examined | 91 | 146 | 88 | 83 | 66 | ||
No of children cured (CR in %) | 88 (96.7 %) | 134 (91.8 %) | 0.7 | 82 (93.2 %) | 76 (91.7 %) | 64 (96.9 %) | 0.5 |
GM egg count/10 ml of urine (95 % CI) | 15.7 (3.7-65.4) | 55.8 (25.5-112.9) | 0.06 | 26.5 (8–87.7) | 67.0 (26.9-166.5) | 25.0 | 0.109 |
ERR in % | 91.1 % | 89.7 % | 0.99 | 88.9 % | 85.3 % | 94.3 % | 0.99 |
Reinfection after treatment (September to November 2011) | |||||||
Follow-up reinfection 2 to 3 months after transmission period in February and March 2012 | |||||||
No. of children infected/examined | 11/142 | 34/183 | 22/141 | 14/103 | 9//81 | ||
Prevalence (95 % CI) | 7.7 % (4.3-13.3) | 18.6 % (13.1-24.8) | 0.010 | 15.6 % (10.5-22.5) | 13.6 % (8.2-21.5) | 11.1 % (5.9-19.8) | 0.486 |
GM egg count/10 ml of urine (95 % CI) | 37.4 (37.4-12.38) | 52.4 (25.2-109.2) | 0.012 | 73.1 (31.8-168.3) | 27.8 (9.4-82.4) | 38.6 (5.6-263.7) | 0.307 |
No. Of children re-infected/surveyed | 8/139 | 22/173 | 16/135 | 8/96 | 6/81 | ||
Reinfection rate (95 % CI) | 5.7 % (2.9-10.9) | 12.7 % (8.5-18.5) | 0.001 | 11.8 % (7.4-18.4) | 8.3 % (4.3-15.6) | 7.4 % (3.4-15.2) | 0.400 |