Efficacy of praziquantel against urinary schistosomiasis and reinfection in Senegalese school children where there is a single well-defined transmission period

Bruno Senghor; Omar Talla Diaw; Souleymane Doucoure; Seydou Nourou Sylla; Mouhamadane Seye; Idrissa Talla; Cheikh Tidiane Bâ; Adiouma Diallo; Cheikh Sokhna

doi:10.1186/s13071-015-0980-5

Table 3 The prevalence and intensity of Schistosoma haematobium infections in children from six villages in the Niakhar study area in Central Senegal at baseline, 5 weeks post treatment and reinfection levels at 2 to 3 months after draining of ponds and backwater, relative to gender and age

From: Efficacy of praziquantel against urinary schistosomiasis and reinfection in Senegalese school children where there is a single well-defined transmission period

Characteristics S. haematobium infection
		Gender			Age
Variables	Female	Male	P-value	5 - 7 years	8 - 10 years	11 - 15 years	P-value
Baseline (June 2011)
No. of children infected/examined	91/142	150/187		88/141	85/105	68/83
Prevalence (95 % CI)	64.1 % (55.9-71.5)	80.2 % (73.9-85.3)	0.001	62.4 % (54.2-69.9)	80.9 % (72.4-87.3)	81.9 % (62.3-88.7)	0.001
Numbers of infected subject treated with PZQ	91	146		88	83	66
GM egg count/10 ml of urine (95 % CI)	177.0 (123.4-253.8)	544.1 (421.4-702.6)	0.001	238.9 (164.4-347.3)	455.6 (313–662.9)	438.7 (299.1-643.3)	<0.001
Treatment (August 2011)
Follow-up efficacy of PZQ 5 weeks post treatment (in September 2011)
No. of children infected/examined	3/142	12/183		6/141	8/103	1/81
Prevalence (95 % CI)	2.1 % (0.7-6)	6.5 % (3.7-10.9)	0.080	4.2 % (1.9-8.9)	7.7 % (3.9-14.4)	1.2 % (0.2-6.7)	0.200
No. of infected treated examined	91	146		88	83	66
No of children cured (CR in %)	88 (96.7 %)	134 (91.8 %)	0.7	82 (93.2 %)	76 (91.7 %)	64 (96.9 %)	0.5
GM egg count/10 ml of urine (95 % CI)	15.7 (3.7-65.4)	55.8 (25.5-112.9)	0.06	26.5 (8–87.7)	67.0 (26.9-166.5)	25.0	0.109
ERR in %	91.1 %	89.7 %	0.99	88.9 %	85.3 %	94.3 %	0.99
Reinfection after treatment (September to November 2011)
Follow-up reinfection 2 to 3 months after transmission period in February and March 2012
No. of children infected/examined	11/142	34/183		22/141	14/103	9//81
Prevalence (95 % CI)	7.7 % (4.3-13.3)	18.6 % (13.1-24.8)	0.010	15.6 % (10.5-22.5)	13.6 % (8.2-21.5)	11.1 % (5.9-19.8)	0.486
GM egg count/10 ml of urine (95 % CI)	37.4 (37.4-12.38)	52.4 (25.2-109.2)	0.012	73.1 (31.8-168.3)	27.8 (9.4-82.4)	38.6 (5.6-263.7)	0.307
No. Of children re-infected/surveyed	8/139	22/173		16/135	8/96	6/81
Reinfection rate (95 % CI)	5.7 % (2.9-10.9)	12.7 % (8.5-18.5)	0.001	11.8 % (7.4-18.4)	8.3 % (4.3-15.6)	7.4 % (3.4-15.2)	0.400

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