Fig. 6
From: Nitric oxide maintains cell survival of Trichomonas vaginalis upon iron depletion
Scheme of the proposed model. In environments without sufficient iron availability, T. vaginalis activates the ubiquitin-proteasome system (UPS) to digest proteins and generate the amino acid arginine. It is likely that ADI, the enzyme with NO synthase activity in the hydrogenosome, utilizes arginine as the source for NO production [14, 32]. NO is crucial for the maintenance of hydrogenosomal function as well as antioxidant capacity. Both mechanisms protect T. vaginalis from iron deficiency-induced damage and prolong the survival of this parasite