Fig. 3

Model for ANISERP-human thrombin binding. a General view of the model for ANISERP binding to human thrombin. The location of the ANISERP reactive centre loop (RCL [green]) in the structural groove of the thrombin is indicated. The thrombin surface is coloured according to its theoretical electrostatic properties (blue = positive, red = negative). b Residues in the heavy chain of human thrombin; binding of amino acids Met358 and Phe374 in ANISERP. c Position of residues in the catalytic triad of human thrombin (His43, Asp99 and Ser205) and their positions relative to ANISERP residues Arg361 and Ser362 (P1 and P1′ respectively). Distances between active residues and atoms in the peptide bond of the substrate, compatible with proteinase activity, are indicated