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Fig. 1 | Parasites & Vectors

Fig. 1

From: Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses

Fig. 1

L. sigmodontis infection in RAG2IL-2Rγ−/− C57BL/6 mice leads to patency. Groups of male WT and Rag2IL-2Rγ−/− C57BL/6 mice were naturally infected with L. sigmodontis. After d30 and 72 p.i. mice were assessed for absolute worm burden (a) and adult female worm length (b). Levels of Wolbachia DNA were determined via a duplex PCR in individual adult female worms (n = 30 Rag2IL-2Rγ−/− and n = 21 C57BL/6) from d30 p.i. (c). Peripheral levels of microfilariae were detected between d49-70 p.i. (d) and on d72 p.i. in blood and TC fluid (e). Symbols in B and C show values from individual worms. Data in A shows values from individual mice on day 30 from n = 10 WT and n = 10 Rag2IL-2Rγ−/− (one infection study) and on d72 in n = 20 WT and n = 16 Rag2IL-2Rγ−/− (three independent infection experiments). Data in D shows Mf counts in n = 8 WT and n = 8 Rag2IL-2Rγ−/− mice within the same infection experiment. E shows Mf counts in individual mice on d72 (n = 20 WT and n = 16 Rag2IL-2Rγ−/−) from three independent infection experiments. Asterisks denote significant differences between the groups indicated by the brackets (***p < 0.001)

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