Fig. 10

Inhibition of AsP38 MAPK altered pyruvate and lactate concentrations in the A. stephensi midgut. A. stephensi were fed a P. falciparum-infected blood meal supplemented with either 10 μM BIRB796 or an equivalent volume of DMSO and 300 midguts/group were collected at 0, 48, and 72 h post-feeding to determine pyruvate and lactate levels. Graphs represent means ± SEMs of 3 independent measurements. Statistical analysis was performed by one-way ANOVA, followed by Bonferroni’s post-test for multiple comparisons between treatments (BIRB796) and controls (DMSO); significant p-values are shown