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Table 1 Proteins over- and under-represented in the A. stephensi midgut following inhibition of AsP38 MAPK signaling

From: Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection

Over-represented proteins following inhibition of AsP38 MAPK

Pathway or process

Accession number

Protein name

UniProt gene name

P value

Carbohydrate metabolism

ASTEI05125

maltase 2 (mal2)

MGAM

0.011

ASTEI02309

maltase

MGAM

0.007

Cytoskeleton/development

ASTEI01099

thymosin

TMSNB

0.041

 

ASTEI03296

dynamin

DNM

0.023

 

ASTEI04270

gelsolin

GSN

0.036

 

ASTEI05229

collagen alpha-1 chain

COLA1

0.008

 

ASTEI08311

myosin

MYH

0.001

 

ASTEI11230

coracle

CORA

0.001

Lysosomes

ASTEI08520

v-type proton ATPase subunit c

VATC

0.023

Mitochondria

ASTEI11442

NADH dehydrogenase 1 beta subcomplex subunit 10

NDUFB10

0.020

 

ASTEI08224

60 kDa heat shock mitochondrial

HSP60

0.006

Membrane fusion/exocytosis

ASTEI07544

synaptosomal-associated protein 25

SNAP25

0.003

 

ASTEI07916

Nipsnap

NIPSNAP1

0.008

Under-represented proteins following inhibition of AsP38 MAPK

Pathway or process

Accession number

Protein name

UniProt gene name

P value

Glycolysis

ASTEI06800

hexokinase type 2

HK2

0.023

 

ASTEI05709

triosephosphate isomerase

TPI1

0.019

 

ASTEI07469

pyruvate kinase

PKM

0.009

Pentose phosphate shunt

ASTEI07641

6-phosphogluconate dehydrogenase

PGD

0.027

Fatty acid biosynthesis/quinone reductase

ASTEI07966

3-ketoacyl-acyl carrier protein reductase

FABG

0.009

Mitochondrial ketone body metabolism

ASTEI05771

succinyl-ligase subunit

SUCLA2

0.034

Mitochondrial OXPHOS

ASTEI01282

succinate dehydrogenase iron-sulfur

SDHB

0.052

 

ASTEI05686

NADH-ubiquinone oxidoreductase/75 kD

NDUFS1

0.029

 

ASTEI10851

cytochrome c oxidase subunit vIIa

COX7A1

0.034

 

ASTEI09954

ATPase subunit F

ATP5F

0.004

 

ASTEI02184

3-hydroxybutyrate dehydrogenase

HIBADH

0.047

Mitochondrial Krebs cycle

ASTEI01282

succinate dehydrogenase iron-sulfur

SDHB

0.052

Mitochondrial protein import/processing

ASTEI04325

putative inner membrane protein

IMMT

0.012

 

ASTEI06526

porin

VDAC

0.005

Mitochondrial dynamics

ASTEI08858

kinesin heavy chain

KIF5B

0.009

Mitochondrial antioxidant defenses

ASTEI07113

superoxide dismutase 2

SOD2

0.006

Ribosomes/translation

ASTEI06447

40s ribosomal protein s16

RPS16

0.053

 

ASTEI09012

40s ribosomal protein s19a

RPS19A

0.015

 

ASTEI08714

40s ribosomal protein s3

RPS3

0.017

 

ASTEI09336

40s ribosomal protein s3a

RPS3A

0.021

 

ASTEI09193

40s ribosomal protein sa

RPSA

0.006

 

ASTEI01139

60s ribosomal protein L10

RPL10

0.026

 

ASTEI04204

60s ribosomal protein L10a

RPL10A

0.015

 

ASTEI00128

60s ribosomal protein L13

RPL13

0.028

 

ASTEI09035

60s ribosomal protein L15

RPL15

0.001

 

ASTEI01482

60s ribosomal protein L18

RPL18

0.053

 

ASTEI07898

60s ribosomal protein L23

RPL23

0.022

 

ASTEI08588

60s ribosomal protein L27a

RPL27A

0.002

 

ASTEI05093

60s ribosomal protein L31

RPL31

0.020

 

ASTEI00059

60s ribosomal protein L36

RPL36

0.038

 

ASTEI00185

60s ribosomal protein L4

RPL4

0.007

 

ASTEI10247

60s ribosomal protein L5

RPL5

0.001

 

ASTEI01907

60s ribosomal protein L7

RPL7

0.010

 

ASTEI063681

heterogeneous nuclear ribonucleoprotein 40

HNRNPH1

0.034

 

ASTEI05590

polyadenylate-binding protein

PABP

0.048

 

ASTEI08624

nascent polypeptide-associated complex subunit alpha

NACA

0.027

 

ASTEI11090

signal recognition particle receptor, alpha homolog

SRPR

0.033

 

ASTEI02606

eukaryotic translation initiation factor 3 subunit e

EIF3E

0.038

 

ASTEI02686

eukaryotic translation initiation factor 3 subunit i

EIF3I

0.039

 

ASTEI012841

RNA-binding protein 1

RBP1

0.005

 

ASTEI06323

ribosomal protein l14

RPL14

0.000

 

ASTEI06775

rRNA 2-o-methyltransferase fibrillarin

FBL

0.022

 

ASTEI01829

cchc-type zinc finger protein

ZCRB1

0.034

 

ASTEI10281

nipped-b protein

NIPBL

0.017

Antioxidant/detoxification

ASTEI10644

catalase

CAT

0.022

 

ASTEI07113

superoxide dismutase 2

SOD2

0.006

 

ASTEI03473

aldehyde dehydrogenase family 7 member a1 homolog

ALDH7A1

0.003

 

ASTEI06895

cytochrome b 5

CYB5

0.040

Proteolysis/lysosomes

ASTEI07459

membrane alanyl aminopeptidase

ANPEP

0.001

 

ASTEI09440

hypodermin c

 

0.045

 

ASTEI10033

chymotrypsin-2

CTRB1

0.008

 

ASTEI07899

proteasome subunit alpha type-1

PSMA1

0.039

 

ASTEI00715

endochitinase

CHIT1

0.045

 

ASTEI10979

v-atpase subunit h

ATP6V1H

0.047

 

ASTEI07458

aminopeptidase n

ANPEP

0.027

 

ASTEI03577

acylsphingosine deacylase

ASAH1

0.012

Endocytosis

ASTEI09008

Ras-related protein Rab-18-b

RAB18

0.017

 

ASTEI10979

v-atpase subunit h

ATP6V1H

0.047

 

ASTEI03296

dynamin

DNM

0.023

 

ASTEI01514

ocia domain-containing protein 1

OCIAD1

0.039

Iron storage

ASTEI00707

ferritin heavy chain

FTH1

0.031

Signal transduction

ASTEI02790

guanine nucleotide-binding protein subunit beta-1

GNB1

0.003

 

ASTEI00708

protein ubash3a homolog

UBASH3A

0.016

 

ASTEI05550

phosphatidylethanolamine-binding protein

PEBP1

0.005