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Table 1 Proteins over- and under-represented in the A. stephensi midgut following inhibition of AsP38 MAPK signaling

From: Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection

Over-represented proteins following inhibition of AsP38 MAPK
Pathway or process Accession number Protein name UniProt gene name P value
Carbohydrate metabolism ASTEI05125 maltase 2 (mal2) MGAM 0.011
ASTEI02309 maltase MGAM 0.007
Cytoskeleton/development ASTEI01099 thymosin TMSNB 0.041
  ASTEI03296 dynamin DNM 0.023
  ASTEI04270 gelsolin GSN 0.036
  ASTEI05229 collagen alpha-1 chain COLA1 0.008
  ASTEI08311 myosin MYH 0.001
  ASTEI11230 coracle CORA 0.001
Lysosomes ASTEI08520 v-type proton ATPase subunit c VATC 0.023
Mitochondria ASTEI11442 NADH dehydrogenase 1 beta subcomplex subunit 10 NDUFB10 0.020
  ASTEI08224 60 kDa heat shock mitochondrial HSP60 0.006
Membrane fusion/exocytosis ASTEI07544 synaptosomal-associated protein 25 SNAP25 0.003
  ASTEI07916 Nipsnap NIPSNAP1 0.008
Under-represented proteins following inhibition of AsP38 MAPK
Pathway or process Accession number Protein name UniProt gene name P value
Glycolysis ASTEI06800 hexokinase type 2 HK2 0.023
  ASTEI05709 triosephosphate isomerase TPI1 0.019
  ASTEI07469 pyruvate kinase PKM 0.009
Pentose phosphate shunt ASTEI07641 6-phosphogluconate dehydrogenase PGD 0.027
Fatty acid biosynthesis/quinone reductase ASTEI07966 3-ketoacyl-acyl carrier protein reductase FABG 0.009
Mitochondrial ketone body metabolism ASTEI05771 succinyl-ligase subunit SUCLA2 0.034
Mitochondrial OXPHOS ASTEI01282 succinate dehydrogenase iron-sulfur SDHB 0.052
  ASTEI05686 NADH-ubiquinone oxidoreductase/75 kD NDUFS1 0.029
  ASTEI10851 cytochrome c oxidase subunit vIIa COX7A1 0.034
  ASTEI09954 ATPase subunit F ATP5F 0.004
  ASTEI02184 3-hydroxybutyrate dehydrogenase HIBADH 0.047
Mitochondrial Krebs cycle ASTEI01282 succinate dehydrogenase iron-sulfur SDHB 0.052
Mitochondrial protein import/processing ASTEI04325 putative inner membrane protein IMMT 0.012
  ASTEI06526 porin VDAC 0.005
Mitochondrial dynamics ASTEI08858 kinesin heavy chain KIF5B 0.009
Mitochondrial antioxidant defenses ASTEI07113 superoxide dismutase 2 SOD2 0.006
Ribosomes/translation ASTEI06447 40s ribosomal protein s16 RPS16 0.053
  ASTEI09012 40s ribosomal protein s19a RPS19A 0.015
  ASTEI08714 40s ribosomal protein s3 RPS3 0.017
  ASTEI09336 40s ribosomal protein s3a RPS3A 0.021
  ASTEI09193 40s ribosomal protein sa RPSA 0.006
  ASTEI01139 60s ribosomal protein L10 RPL10 0.026
  ASTEI04204 60s ribosomal protein L10a RPL10A 0.015
  ASTEI00128 60s ribosomal protein L13 RPL13 0.028
  ASTEI09035 60s ribosomal protein L15 RPL15 0.001
  ASTEI01482 60s ribosomal protein L18 RPL18 0.053
  ASTEI07898 60s ribosomal protein L23 RPL23 0.022
  ASTEI08588 60s ribosomal protein L27a RPL27A 0.002
  ASTEI05093 60s ribosomal protein L31 RPL31 0.020
  ASTEI00059 60s ribosomal protein L36 RPL36 0.038
  ASTEI00185 60s ribosomal protein L4 RPL4 0.007
  ASTEI10247 60s ribosomal protein L5 RPL5 0.001
  ASTEI01907 60s ribosomal protein L7 RPL7 0.010
  ASTEI063681 heterogeneous nuclear ribonucleoprotein 40 HNRNPH1 0.034
  ASTEI05590 polyadenylate-binding protein PABP 0.048
  ASTEI08624 nascent polypeptide-associated complex subunit alpha NACA 0.027
  ASTEI11090 signal recognition particle receptor, alpha homolog SRPR 0.033
  ASTEI02606 eukaryotic translation initiation factor 3 subunit e EIF3E 0.038
  ASTEI02686 eukaryotic translation initiation factor 3 subunit i EIF3I 0.039
  ASTEI012841 RNA-binding protein 1 RBP1 0.005
  ASTEI06323 ribosomal protein l14 RPL14 0.000
  ASTEI06775 rRNA 2-o-methyltransferase fibrillarin FBL 0.022
  ASTEI01829 cchc-type zinc finger protein ZCRB1 0.034
  ASTEI10281 nipped-b protein NIPBL 0.017
Antioxidant/detoxification ASTEI10644 catalase CAT 0.022
  ASTEI07113 superoxide dismutase 2 SOD2 0.006
  ASTEI03473 aldehyde dehydrogenase family 7 member a1 homolog ALDH7A1 0.003
  ASTEI06895 cytochrome b 5 CYB5 0.040
Proteolysis/lysosomes ASTEI07459 membrane alanyl aminopeptidase ANPEP 0.001
  ASTEI09440 hypodermin c   0.045
  ASTEI10033 chymotrypsin-2 CTRB1 0.008
  ASTEI07899 proteasome subunit alpha type-1 PSMA1 0.039
  ASTEI00715 endochitinase CHIT1 0.045
  ASTEI10979 v-atpase subunit h ATP6V1H 0.047
  ASTEI07458 aminopeptidase n ANPEP 0.027
  ASTEI03577 acylsphingosine deacylase ASAH1 0.012
Endocytosis ASTEI09008 Ras-related protein Rab-18-b RAB18 0.017
  ASTEI10979 v-atpase subunit h ATP6V1H 0.047
  ASTEI03296 dynamin DNM 0.023
  ASTEI01514 ocia domain-containing protein 1 OCIAD1 0.039
Iron storage ASTEI00707 ferritin heavy chain FTH1 0.031
Signal transduction ASTEI02790 guanine nucleotide-binding protein subunit beta-1 GNB1 0.003
  ASTEI00708 protein ubash3a homolog UBASH3A 0.016
  ASTEI05550 phosphatidylethanolamine-binding protein PEBP1 0.005