Over-represented proteins following inhibition of AsP38 MAPK | ||||
---|---|---|---|---|
Pathway or process | Accession number | Protein name | UniProt gene name | P value |
Carbohydrate metabolism | ASTEI05125 | maltase 2 (mal2) | MGAM | 0.011 |
ASTEI02309 | maltase | MGAM | 0.007 | |
Cytoskeleton/development | ASTEI01099 | thymosin | TMSNB | 0.041 |
 | ASTEI03296 | dynamin | DNM | 0.023 |
 | ASTEI04270 | gelsolin | GSN | 0.036 |
 | ASTEI05229 | collagen alpha-1 chain | COLA1 | 0.008 |
 | ASTEI08311 | myosin | MYH | 0.001 |
 | ASTEI11230 | coracle | CORA | 0.001 |
Lysosomes | ASTEI08520 | v-type proton ATPase subunit c | VATC | 0.023 |
Mitochondria | ASTEI11442 | NADH dehydrogenase 1 beta subcomplex subunit 10 | NDUFB10 | 0.020 |
 | ASTEI08224 | 60 kDa heat shock mitochondrial | HSP60 | 0.006 |
Membrane fusion/exocytosis | ASTEI07544 | synaptosomal-associated protein 25 | SNAP25 | 0.003 |
 | ASTEI07916 | Nipsnap | NIPSNAP1 | 0.008 |
Under-represented proteins following inhibition of AsP38 MAPK | ||||
Pathway or process | Accession number | Protein name | UniProt gene name | P value |
Glycolysis | ASTEI06800 | hexokinase type 2 | HK2 | 0.023 |
 | ASTEI05709 | triosephosphate isomerase | TPI1 | 0.019 |
 | ASTEI07469 | pyruvate kinase | PKM | 0.009 |
Pentose phosphate shunt | ASTEI07641 | 6-phosphogluconate dehydrogenase | PGD | 0.027 |
Fatty acid biosynthesis/quinone reductase | ASTEI07966 | 3-ketoacyl-acyl carrier protein reductase | FABG | 0.009 |
Mitochondrial ketone body metabolism | ASTEI05771 | succinyl-ligase subunit | SUCLA2 | 0.034 |
Mitochondrial OXPHOS | ASTEI01282 | succinate dehydrogenase iron-sulfur | SDHB | 0.052 |
 | ASTEI05686 | NADH-ubiquinone oxidoreductase/75 kD | NDUFS1 | 0.029 |
 | ASTEI10851 | cytochrome c oxidase subunit vIIa | COX7A1 | 0.034 |
 | ASTEI09954 | ATPase subunit F | ATP5F | 0.004 |
 | ASTEI02184 | 3-hydroxybutyrate dehydrogenase | HIBADH | 0.047 |
Mitochondrial Krebs cycle | ASTEI01282 | succinate dehydrogenase iron-sulfur | SDHB | 0.052 |
Mitochondrial protein import/processing | ASTEI04325 | putative inner membrane protein | IMMT | 0.012 |
 | ASTEI06526 | porin | VDAC | 0.005 |
Mitochondrial dynamics | ASTEI08858 | kinesin heavy chain | KIF5B | 0.009 |
Mitochondrial antioxidant defenses | ASTEI07113 | superoxide dismutase 2 | SOD2 | 0.006 |
Ribosomes/translation | ASTEI06447 | 40s ribosomal protein s16 | RPS16 | 0.053 |
 | ASTEI09012 | 40s ribosomal protein s19a | RPS19A | 0.015 |
 | ASTEI08714 | 40s ribosomal protein s3 | RPS3 | 0.017 |
 | ASTEI09336 | 40s ribosomal protein s3a | RPS3A | 0.021 |
 | ASTEI09193 | 40s ribosomal protein sa | RPSA | 0.006 |
 | ASTEI01139 | 60s ribosomal protein L10 | RPL10 | 0.026 |
 | ASTEI04204 | 60s ribosomal protein L10a | RPL10A | 0.015 |
 | ASTEI00128 | 60s ribosomal protein L13 | RPL13 | 0.028 |
 | ASTEI09035 | 60s ribosomal protein L15 | RPL15 | 0.001 |
 | ASTEI01482 | 60s ribosomal protein L18 | RPL18 | 0.053 |
 | ASTEI07898 | 60s ribosomal protein L23 | RPL23 | 0.022 |
 | ASTEI08588 | 60s ribosomal protein L27a | RPL27A | 0.002 |
 | ASTEI05093 | 60s ribosomal protein L31 | RPL31 | 0.020 |
 | ASTEI00059 | 60s ribosomal protein L36 | RPL36 | 0.038 |
 | ASTEI00185 | 60s ribosomal protein L4 | RPL4 | 0.007 |
 | ASTEI10247 | 60s ribosomal protein L5 | RPL5 | 0.001 |
 | ASTEI01907 | 60s ribosomal protein L7 | RPL7 | 0.010 |
 | ASTEI063681 | heterogeneous nuclear ribonucleoprotein 40 | HNRNPH1 | 0.034 |
 | ASTEI05590 | polyadenylate-binding protein | PABP | 0.048 |
 | ASTEI08624 | nascent polypeptide-associated complex subunit alpha | NACA | 0.027 |
 | ASTEI11090 | signal recognition particle receptor, alpha homolog | SRPR | 0.033 |
 | ASTEI02606 | eukaryotic translation initiation factor 3 subunit e | EIF3E | 0.038 |
 | ASTEI02686 | eukaryotic translation initiation factor 3 subunit i | EIF3I | 0.039 |
 | ASTEI012841 | RNA-binding protein 1 | RBP1 | 0.005 |
 | ASTEI06323 | ribosomal protein l14 | RPL14 | 0.000 |
 | ASTEI06775 | rRNA 2-o-methyltransferase fibrillarin | FBL | 0.022 |
 | ASTEI01829 | cchc-type zinc finger protein | ZCRB1 | 0.034 |
 | ASTEI10281 | nipped-b protein | NIPBL | 0.017 |
Antioxidant/detoxification | ASTEI10644 | catalase | CAT | 0.022 |
 | ASTEI07113 | superoxide dismutase 2 | SOD2 | 0.006 |
 | ASTEI03473 | aldehyde dehydrogenase family 7 member a1 homolog | ALDH7A1 | 0.003 |
 | ASTEI06895 | cytochrome b 5 | CYB5 | 0.040 |
Proteolysis/lysosomes | ASTEI07459 | membrane alanyl aminopeptidase | ANPEP | 0.001 |
 | ASTEI09440 | hypodermin c |  | 0.045 |
 | ASTEI10033 | chymotrypsin-2 | CTRB1 | 0.008 |
 | ASTEI07899 | proteasome subunit alpha type-1 | PSMA1 | 0.039 |
 | ASTEI00715 | endochitinase | CHIT1 | 0.045 |
 | ASTEI10979 | v-atpase subunit h | ATP6V1H | 0.047 |
 | ASTEI07458 | aminopeptidase n | ANPEP | 0.027 |
 | ASTEI03577 | acylsphingosine deacylase | ASAH1 | 0.012 |
Endocytosis | ASTEI09008 | Ras-related protein Rab-18-b | RAB18 | 0.017 |
 | ASTEI10979 | v-atpase subunit h | ATP6V1H | 0.047 |
 | ASTEI03296 | dynamin | DNM | 0.023 |
 | ASTEI01514 | ocia domain-containing protein 1 | OCIAD1 | 0.039 |
Iron storage | ASTEI00707 | ferritin heavy chain | FTH1 | 0.031 |
Signal transduction | ASTEI02790 | guanine nucleotide-binding protein subunit beta-1 | GNB1 | 0.003 |
 | ASTEI00708 | protein ubash3a homolog | UBASH3A | 0.016 |
 | ASTEI05550 | phosphatidylethanolamine-binding protein | PEBP1 | 0.005 |