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Table 3 Over-represented pathways in the A. stephensi midgut upon BIRB796-mediated inhibition of AsP38 MAPK

From: Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection

Pathway namea

Pathway ID

Pathway uploaded gene count

Genes in InnateDB for this entity

Pathway p-value

Pathway p-value (corrected)

Gene symbols

Ribosome

474

17

87

2.89E-23

1.53E-22

RPL10; RPL10A; RPL13; RPL14; RPL15; RPL18; RPL23; RPL27A; RPL31; RPL4; RPL5; RPL7; RPS16; RPS19; RPS3; RPS3A; RPSA

Oxidative phosphorylation

576

4

131

6.09E-05

2.31E-04

COX7A1; NDUFB10; NDUFS1; SDHB

Glycolysis/Gluconeogenesis

414

4

64

3.51E-04

0.001

ALDH7A1; HK2; PKM2; TPI1

Metabolic pathways

4373

15

1115

4.20E-04

0.001

ALDH7A1; ANPEP; ASAH1; ATP6V1C1; ATP6V1H; HIBADH; HK2; MGAM; NDUFB10; NDUFS1; PGD; PKM2; SDHB; SUCLA2; TPI1

Galactose metabolism

407

2

27

0.009

0.021

HK2; MGAM

Citrate cycle (TCA cycle)

464

2

30

0.011

0.021

SDHB; SUCLA2

Propanoate metabolism

472

2

32

0.012

0.023

ALDH7A1; SUCLA2

Fructose and mannose metabolism

548

2

35

0.015

0.025

HK2; TPI1

Carbohydrate digestion and absorption

10389

2

41

0.020

0.031

HK2; MGAM

Pyruvate metabolism

450

2

40

0.019

0.031

ALDH7A1; PKM2

Valine, leucine and isoleucine degradation

453

2

44

0.023

0.034

ALDH7A1; HIBADH

Amino sugar and nucleotide sugar metabolism

466

2

48

0.027

0.035

CHIT1; HK2

Glutathione metabolism

534

2

48

0.027

0.035

ANPEP; PGD

Starch and sucrose metabolism

536

2

49

0.028

0.036

HK2; MGAM

Epithelial cell signaling in infection

420

2

54

0.033

0.040

ATP6V1C1; ATP6V1H

RNA transport

10361

3

149

0.044

0.052

EIF3E; EIF3I; PABPC1

RNA degradation

5710

2

68

0.050

0.056

HSPD1; PABPC1

Lysosome

4356

2

121

0.135

0.143

ASAH1; ATP6V1H

Phagosome

10394

2

145

0.180

0.187

ATP6V1C1; ATP6V1H

  1. aData from TableĀ 1 were utilized to run a hypergeometric algorithm following a Benjamini-Hochberg correction for significance. Pathways not relevant to mosquito metabolism were deleted from the analysis