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Table 3 Over-represented pathways in the A. stephensi midgut upon BIRB796-mediated inhibition of AsP38 MAPK

From: Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection

Pathway namea Pathway ID Pathway uploaded gene count Genes in InnateDB for this entity Pathway p-value Pathway p-value (corrected) Gene symbols
Ribosome 474 17 87 2.89E-23 1.53E-22 RPL10; RPL10A; RPL13; RPL14; RPL15; RPL18; RPL23; RPL27A; RPL31; RPL4; RPL5; RPL7; RPS16; RPS19; RPS3; RPS3A; RPSA
Oxidative phosphorylation 576 4 131 6.09E-05 2.31E-04 COX7A1; NDUFB10; NDUFS1; SDHB
Glycolysis/Gluconeogenesis 414 4 64 3.51E-04 0.001 ALDH7A1; HK2; PKM2; TPI1
Metabolic pathways 4373 15 1115 4.20E-04 0.001 ALDH7A1; ANPEP; ASAH1; ATP6V1C1; ATP6V1H; HIBADH; HK2; MGAM; NDUFB10; NDUFS1; PGD; PKM2; SDHB; SUCLA2; TPI1
Galactose metabolism 407 2 27 0.009 0.021 HK2; MGAM
Citrate cycle (TCA cycle) 464 2 30 0.011 0.021 SDHB; SUCLA2
Propanoate metabolism 472 2 32 0.012 0.023 ALDH7A1; SUCLA2
Fructose and mannose metabolism 548 2 35 0.015 0.025 HK2; TPI1
Carbohydrate digestion and absorption 10389 2 41 0.020 0.031 HK2; MGAM
Pyruvate metabolism 450 2 40 0.019 0.031 ALDH7A1; PKM2
Valine, leucine and isoleucine degradation 453 2 44 0.023 0.034 ALDH7A1; HIBADH
Amino sugar and nucleotide sugar metabolism 466 2 48 0.027 0.035 CHIT1; HK2
Glutathione metabolism 534 2 48 0.027 0.035 ANPEP; PGD
Starch and sucrose metabolism 536 2 49 0.028 0.036 HK2; MGAM
Epithelial cell signaling in infection 420 2 54 0.033 0.040 ATP6V1C1; ATP6V1H
RNA transport 10361 3 149 0.044 0.052 EIF3E; EIF3I; PABPC1
RNA degradation 5710 2 68 0.050 0.056 HSPD1; PABPC1
Lysosome 4356 2 121 0.135 0.143 ASAH1; ATP6V1H
Phagosome 10394 2 145 0.180 0.187 ATP6V1C1; ATP6V1H
  1. aData from TableĀ 1 were utilized to run a hypergeometric algorithm following a Benjamini-Hochberg correction for significance. Pathways not relevant to mosquito metabolism were deleted from the analysis