Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection

Table 3 Over-represented pathways in the A. stephensi midgut upon BIRB796-mediated inhibition of AsP38 MAPK

Pathway name^a	Pathway ID	Pathway uploaded gene count	Genes in InnateDB for this entity	Pathway p-value	Pathway p-value (corrected)	Gene symbols
Ribosome	474	17	87	2.89E-23	1.53E-22	RPL10; RPL10A; RPL13; RPL14; RPL15; RPL18; RPL23; RPL27A; RPL31; RPL4; RPL5; RPL7; RPS16; RPS19; RPS3; RPS3A; RPSA
Oxidative phosphorylation	576	4	131	6.09E-05	2.31E-04	COX7A1; NDUFB10; NDUFS1; SDHB
Glycolysis/Gluconeogenesis	414	4	64	3.51E-04	0.001	ALDH7A1; HK2; PKM2; TPI1
Metabolic pathways	4373	15	1115	4.20E-04	0.001	ALDH7A1; ANPEP; ASAH1; ATP6V1C1; ATP6V1H; HIBADH; HK2; MGAM; NDUFB10; NDUFS1; PGD; PKM2; SDHB; SUCLA2; TPI1
Galactose metabolism	407	2	27	0.009	0.021	HK2; MGAM
Citrate cycle (TCA cycle)	464	2	30	0.011	0.021	SDHB; SUCLA2
Propanoate metabolism	472	2	32	0.012	0.023	ALDH7A1; SUCLA2
Fructose and mannose metabolism	548	2	35	0.015	0.025	HK2; TPI1
Carbohydrate digestion and absorption	10389	2	41	0.020	0.031	HK2; MGAM
Pyruvate metabolism	450	2	40	0.019	0.031	ALDH7A1; PKM2
Valine, leucine and isoleucine degradation	453	2	44	0.023	0.034	ALDH7A1; HIBADH
Amino sugar and nucleotide sugar metabolism	466	2	48	0.027	0.035	CHIT1; HK2
Glutathione metabolism	534	2	48	0.027	0.035	ANPEP; PGD
Starch and sucrose metabolism	536	2	49	0.028	0.036	HK2; MGAM
Epithelial cell signaling in infection	420	2	54	0.033	0.040	ATP6V1C1; ATP6V1H
RNA transport	10361	3	149	0.044	0.052	EIF3E; EIF3I; PABPC1
RNA degradation	5710	2	68	0.050	0.056	HSPD1; PABPC1
Lysosome	4356	2	121	0.135	0.143	ASAH1; ATP6V1H
Phagosome	10394	2	145	0.180	0.187	ATP6V1C1; ATP6V1H

^aData from Table 1 were utilized to run a hypergeometric algorithm following a Benjamini-Hochberg correction for significance. Pathways not relevant to mosquito metabolism were deleted from the analysis

ISSN: 1756-3305