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Table 6 Cytokine profiles corresponding to the mice splenocytes cultivated in the presence of phytoecdysteroids and concanavalin A

From: Phytoecdysteroids as modulators of the Toxoplasma gondii growth rate in human and mouse cells

  Cytokine levels [pg/mL]
Splenocytes control α-ecdysone 20-hydroxyecdysone ConA
IFN-γ
0 2 10 20 2 20 100 2.5
BALB/c mean 752.33 606.89 552.24 667.61 716.58 709.40 663.52 1997.97*
N = 12 SD 634.53 423.51 438.02 599.92 452.11 568.89 409.02 369.25
negative median 48.28 566.79 498.71 632.57 666.49 657.71 565.57 1857.23
BALB/c mean 1735.99 1000.17 1168.71 1057.95 1540.23 1661.91 1560.54 4307.02*
N = 9 SD 714.81 687.62 843.80 901.84 572.05 604.58 633.65 82.08
positive median 1848.28 878.07 976.23 819.85 1385.37 1485.31 1439.19 4292.66
  IL-10
BALB/c mean 19.49 20.84 18.87 19.60 21.39 19.20 20.54 1987.46*
N = 12 SD 9.08 13.12 7.80 10.45 8.12 8.85 9.55 340.02
negative median 16.30 18.58 16.08 17.56 19.86 17.48 18.96 1883.19
BALB/c mean 1344.07 1351.45 1385.59 1426.28 1550.71 1390.64 1437.98 2531.09*
N = 9 SD 583.19 543.89 550.90 522.69 506.47 494.77 521.20 661.58
positive median 972.59 975.12 1006.89 1084.91 1228.71 1158.47 1079.78 2878.76
  IL-2
BALB/c mean 11.58 9.85 9.04 9.64 9.54 10.63 9.71 159.12*
N = 10 SD 9.76 2,55 3.32 3.21 3.82 3.79 3.23 30.02
negative median 10.03 8.01 7.96 7.86 7.32 8.56 8.56 143.45
BALB/c mean 16.22 21.82 15.88 19.91 19.31 19.80 20.98 276.97*
N = 10 SD 10.25 11.48 8.83 13.63 15.55 12.89 13.42 42.75
positive median 15.25 17.77 14.25 16.45 13.55 15.50 19.05 290.12
  1. Splenocytes were derived from BALB/c mice uninfected (T. gondii-seronegative) and chronically infected with T. gondii DX strain (T. gondii-seropositive). The statistically significant differences (p < 0.05) were labeled with an asterisk (*)