Table 7 Cytokine profiles corresponding to the splenocytes infected by T. gondii and cultivated in the presence of phytoecdysteroids or concanavalin A
From: Phytoecdysteroids as modulators of the Toxoplasma gondii growth rate in human and mouse cells
Cytokine levels [pg/mL] | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Splenocytes and toxoplasma | control | α-ecdysone | 20-hydroxyecdysone | ConA | |||||
IFN-γ | |||||||||
0 | 2 | 10 | 20 | 2 | 20 | 100 | 2.5 | ||
BALB/c | mean | 1776.41 | 1748.22 | 1809.40 | 1263.67* | 1431.23 | 908.90* | 1860.88 | 2236.53* |
N = 14 | SD | 672.75 | 452.11 | 568.89 | 109.02 | 760.64 | 200.90 | 1275.54 | 469.06 |
negative | median | 1626.60 | 1666.49 | 1884.71 | 1265.57 | 1303.56 | 898.47 | 1854.40 | 1952.70 |
BALB/c | mean | 2081.82 | 2983.11 | 2907.12 | 2912.51 | 2965.06 | 2884.66 | 2950.60 | 4159.40* |
N = 10 | SD | 1253.55 | 1390.12 | 1445.01 | 1497.61 | 1541.11 | 1531.37 | 1477.52 | 322.44 |
positive | median | 1604.36 | 3972.21 | 3812.13 | 3954.39 | 4070.46 | 3987.08 | 3984.11 | 4198.95 |
C57Bl/6 | mean | 816.88 | 790.06 | 749.12 | 827.65 | 639.40 | 652.87 | 765.19 | 3569.88* |
N = 10 | SD | 326.21 | 278.98 | 237.76 | 232.67 | 232.76 | 245.14 | 219.75 | 378.49 |
negative | median | 787.18 | 698.90 | 678.65 | 743.09 | 606.98 | 120.28 | 136.92 | 3339.78 |
IL-10 | |||||||||
BALB/c | mean | 534.73 | 531.39 | 538.11 | 639.41 | 631.99 | 535.42 | 631.71 | 1987.46* |
N = 14 | SD | 369.76 | 367.85 | 317.15 | 411.98 | 310.57 | 410.32 | 418.65 | 440.02 |
negative | median | 532.30 | 531.08 | 532.00 | 636.93 | 629.86 | 533.53 | 528.94 | 2083.19 |
BALB/c | mean | 1836.67 | 2054.01 | 1783.78 | 1907.01 | 2252.42 | 1981.89 | 1942.38 | 3157.88* |
N = 10 | SD | 387.73 | 579.95 | 716.93 | 499.15 | 592.62 | 392.76 | 433.08 | 1186.99 |
positive | median | 1638.48 | 1952.01 | 1540.04 | 1691.38 | 1946.47 | 1760.87 | 1821.10 | 3615.60 |
C57Bl/6 | mean | 28.73 | 30.68 | 33.36 | 28.94 | 29.59 | 31.75 | 25.98 | 516.83* |
N = 9 | SD | 20.33 | 24.72 | 27.19 | 19.04 | 17.88 | 16.70 | 19.85 | 378.49 |
negative | median | 25.46 | 28.56 | 29.46 | 25.98 | 26.58 | 29.87 | 34.56 | 501.78 |
IL-2 | |||||||||
BALB/c | mean | 22.98 | 20.22 | 20.69 | 23.24 | 21.45 | 26.25 | 24.47 | 163.68* |
N = 10 | SD | 20.69 | 19.85 | 19.87 | 18.23 | 16.59 | 20.69 | 20.58 | 54,76 |
negative | median | 21.20 | 20.30 | 19.58 | 19.23 | 19.96 | 19.65 | 22.87 | 139.78 |
BALB/c | mean | 124.42 | 151.08 | 130.26 | 140.97 | 149.61 | 146.26 | 166.44 | 339.63* |
N = 10 | SD | 69.58 | 64.59 | 56.79 | 56.89 | 76.40 | 72.27 | 69.21 | 14.84 |
positive | median | 87.18 | 120.20 | 116.25 | 125.37 | 131.56 | 120.28 | 136.92 | 339.78 |
C57Bl/6 | mean | 12.54 | 10.02 | 10.17 | 10.29 | 11.42 | 12.26 | 11.87 | 163.68* |
N = 10 | SD | 10.70 | 9.08 | 9.57 | 8.92 | 6.38 | 10.84 | 10.10 | 54,76 |
negative | median | 10.25 | 10.00 | 9.25 | 9.98 | 10.25 | 10.24 | 10.36 | 139.78 |