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Table 7 Cytokine profiles corresponding to the splenocytes infected by T. gondii and cultivated in the presence of phytoecdysteroids or concanavalin A

From: Phytoecdysteroids as modulators of the Toxoplasma gondii growth rate in human and mouse cells

  Cytokine levels [pg/mL]
Splenocytes and toxoplasma control α-ecdysone 20-hydroxyecdysone ConA
IFN-γ
0 2 10 20 2 20 100 2.5
BALB/c mean 1776.41 1748.22 1809.40 1263.67* 1431.23 908.90* 1860.88 2236.53*
N = 14 SD 672.75 452.11 568.89 109.02 760.64 200.90 1275.54 469.06
negative median 1626.60 1666.49 1884.71 1265.57 1303.56 898.47 1854.40 1952.70
BALB/c mean 2081.82 2983.11 2907.12 2912.51 2965.06 2884.66 2950.60 4159.40*
N = 10 SD 1253.55 1390.12 1445.01 1497.61 1541.11 1531.37 1477.52 322.44
positive median 1604.36 3972.21 3812.13 3954.39 4070.46 3987.08 3984.11 4198.95
C57Bl/6 mean 816.88 790.06 749.12 827.65 639.40 652.87 765.19 3569.88*
N = 10 SD 326.21 278.98 237.76 232.67 232.76 245.14 219.75 378.49
negative median 787.18 698.90 678.65 743.09 606.98 120.28 136.92 3339.78
  IL-10
BALB/c mean 534.73 531.39 538.11 639.41 631.99 535.42 631.71 1987.46*
N = 14 SD 369.76 367.85 317.15 411.98 310.57 410.32 418.65 440.02
negative median 532.30 531.08 532.00 636.93 629.86 533.53 528.94 2083.19
BALB/c mean 1836.67 2054.01 1783.78 1907.01 2252.42 1981.89 1942.38 3157.88*
N = 10 SD 387.73 579.95 716.93 499.15 592.62 392.76 433.08 1186.99
positive median 1638.48 1952.01 1540.04 1691.38 1946.47 1760.87 1821.10 3615.60
C57Bl/6 mean 28.73 30.68 33.36 28.94 29.59 31.75 25.98 516.83*
N = 9 SD 20.33 24.72 27.19 19.04 17.88 16.70 19.85 378.49
negative median 25.46 28.56 29.46 25.98 26.58 29.87 34.56 501.78
  IL-2
BALB/c mean 22.98 20.22 20.69 23.24 21.45 26.25 24.47 163.68*
N = 10 SD 20.69 19.85 19.87 18.23 16.59 20.69 20.58 54,76
negative median 21.20 20.30 19.58 19.23 19.96 19.65 22.87 139.78
BALB/c mean 124.42 151.08 130.26 140.97 149.61 146.26 166.44 339.63*
N = 10 SD 69.58 64.59 56.79 56.89 76.40 72.27 69.21 14.84
positive median 87.18 120.20 116.25 125.37 131.56 120.28 136.92 339.78
C57Bl/6 mean 12.54 10.02 10.17 10.29 11.42 12.26 11.87 163.68*
N = 10 SD 10.70 9.08 9.57 8.92 6.38 10.84 10.10 54,76
negative median 10.25 10.00 9.25 9.98 10.25 10.24 10.36 139.78
  1. Splenocytes were derived from uninfected (T. gondii-seronegative) BALB/c or C57BL/6 as well as from chronically infected with T. gondii DX strain (T. gondii-seropositive) BALB/c mice. The statistically significant differences (p < 0.05) were labeled with an asterisk (*)