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Table 4 In vivo worm burden reductions after a single oral dose of 200 mg/kg (afatinib) or 400 mg/kg body weight (remaining drugs) to mice harboring a chronic S.mansoni infection

From: Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni

Drug Number of mice treated Average worm count (SD) WBR [%]
Control1 8 20.4 (12.4) -
Control2 8 23.0 (18.4) -
Trametinib1,2 5 8.1 (4.1) 63.6
Vandetanib1,2 5 11.3 (8.4) 48.1
Afatinib1 4 14.8 (11.1) 27.5
Ponatinib1 3 16.6 (12.9) 18.6
Sunitinib1 4 22.5 (8.5) 2.2
Bosutinib1 4 25.3 (4.0) 0
  1. P value of all WBRs was > 0.05; Values in superscript refer to the corresponding control group
  2. SD standard deviation