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Fig. 4 | Parasites & Vectors

Fig. 4

From: Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus

Fig. 4

nsP3 interacts with the NTF2-like domain of mosquito Rasputin. a Protein alignment of the Rin/G3BP NTF2-like domains from Ae. albopictus (KP641128), Ae. aegypti, (XP_001651045), Culex quincefasciatus (XP_001861860), Anopheles gambiae (XP_001688309), Anopheles sinensis (KFB40464), Drosophila melanogaster (AF231031), Ixodes ricinus (GANP01009274), and Homo sapiens (CAG38772). Genbank accession numbers in brackets. Alignment made with CLUSTALX and modified using Genedoc. b Structural modeling of Ae. albopictus-Rin modeled onto D. melanogaster Rin. Modeling was performed using the Phyre2 server (, results were visualized with PyMOL ( Left, Ae. albopictus Rin (deep blue) is depicted together with D. melanogaster Rin (cyan). Right, the FxFG binding pocket is shown and phenylalanine 34 is highlighted in red. c Sf21 insect cells were co-transfected with EGFP-nsP3 and either Rin-mCherry (wild type), Rin-mCherry F34A or Rin-mCherry F34W

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